Perennial American League heavyweights will face off on Tuesday night as the Houston Astros (23-13) and Boston Red Sox (14-21) meet for the second game of their three-game series. The Red Sox took the first game on Monday night with a 6-3 win. Jose Urquidy (2-1, 4.40 ERA) will take the ball for Houston, while Nathan Eovaldi (1-1, 3.15 ERA) will be Boston's starter for the MLB on TBS tilt.

First pitch is set for 7:10 ET. Boston is the -130 money-line favorite (risk $130 to win $100) in the latest Red Sox vs. Astros odds from Caesars Sportsbook, while Houston is a +105 underdog. The over-under total sits at 8.5. Before making any Astros vs. Red Sox picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a profitable start to the 2022 season. It's on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen some huge returns.

Now, the model has set its sights on Astros vs. Red Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the picks. Here are several MLB odds and trends for Astros vs. Red Sox: 

  • Astros vs. Red Sox money line: Boston -130, Houston +110
  • Astros vs. Red Sox run line: Boston -1.5 (+170) 
  • Astros vs. Red Sox over-under: 8.5 runs
  • Astros vs. Red Sox tickets: See tickets at StubHub
  • HOU: Astros have won eight of last 10, but also lost two of last three
  • BOS: Red Sox 4-5 as home favorites this season
Featured Game | Boston Red Sox vs. Houston Astros

Why the Astros can cover

Houston second baseman Jose Altuve is a seven-time All-Star and former MVP with formidable offensive skills. Altuve has long been one of the league's best bat-to-ball hitters and boasts surprising pop. Though he doesn't steal bases that often these days, Altuve still has the speed to stretch singles into doubles and take an extra 90 feet to help his offense. He's hitting .259/.351/.518 with seven homers, and went 1-4 with an RBI on Monday. Altuve is hitting .316 in his career against Eovaldi.

Outfielder Michael Brantley is an elite hitter with a history of getting it done in the clutch for the Astros. Though he doesn't put the ball over the fence that often these days, he makes up for it with pure offense and a knack for getting runners in. Brantley is once again having a strong campaign, hitting .281 with 12 RBI. He went 2-4 with a double and a run scored on Monday.

Why the Red Sox can cover

Red Sox third baseman Rafael Devers is leading the league in hits with 47 and is one of the best pure hitters in MLB. He has excellent contact skills to go along with a shrewd batter's eye and serious pop. The former All-Star is hitting a robust .322 -- and he's not even leading his own team in batting average. That honor belongs to shortstop Xander Bogaerts, who's hitting .346. 

Bogaerts, a three-time All-Star and four-time Silver Slugger award-winner, has been a fixture in Boston's lineup for nearly a decade. He's proven himself to be one of the best offensive shortstops in baseball and trails only Los Angeles' Taylor Ward in the American League batting title race. The left side of the Boston infield is an offensive dynamo, and they present a tough task for Urquidy.

How to Make Astros vs. Red Sox picks

SportsLine's model is leaning over on the total, projecting 9.4 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

Will the Astros or Red Sox come out on top? And which team has all the value on the money line? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.