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The Cleveland Guardians host the Chicago White Sox for a matinee matchup on Sunday. The game is the finale of a three-game weekend set at Progressive Field. Sunday's game is also the last matchup between the AL Central rivals in Cleveland this season. Dylan Cease takes the hill for Chicago against Aaron Civale for Cleveland.

First pitch is at 12:05 p.m. ET in Cleveland. Caesars Sportsbook lists Chicago as a -125 favorite (risk $125 to win $100) on the money line, while the over/under, or total number of runs Vegas thinks will be scored, is 7.5 in the latest White Sox vs. Guardians odds. Before you make any Guardians vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 300-260 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Guardians vs. White Sox and revealed its coveted picks and predictions. You can head to SportsLine to see all of the model's MLB picks. Here are several MLB odds and trends for White Sox vs. Guardians:

  • White Sox vs. Guardians money line: White Sox -125, Guardians +105
  • White Sox vs. Guardians over/under: 7.5 runs
  • White Sox vs. Guardians run line: White Sox -1.5 (+135)
  • CHW: The White Sox are 29-24 in day games
  • CLE: The Guardians are 30-24 in day games
  • White Sox vs. Guardians picks: See picks at SportsLine
Featured Game | Cleveland Guardians vs. Chicago White Sox

Why you should back the White Sox

Chicago's projection is buoyed by the presence of Dylan Cease as the team's projected starting pitcher. Cease is enjoying the best season of his career, and the 26-year-old is a Cy Young candidate in the American League. He has a 2.09 ERA for the season, and Cease leads the AL with 11.98 strikeouts per nine innings. Opponents have a .602 OPS against Cease, and he has a 2.12 ERA in three starts against Cleveland in 2022. 

Cease's season-long numbers are stout, but he has been even better lately, including a recent 14-start stretch in which he allowed one earned or fewer in every outing. Cease has a 0.93 ERA since May 29, and he owns a 1.34 ERA on the road this season. Behind him, Chicago has an above-average bullpen that averages more than a strikeout per inning with a top-five mark in the AL in home run rate allowed.

Why you should back the Guardians

Cleveland's offense leads the American League in strikeout avoidance, providing a high baseline in run creation. The Guardians are in the top four of the AL in hits, doubles, triples, stolen bases, and batting average, and Cleveland is above the AL average in slugging percentage, OPS, on-base percentage, and runs scored. 

On the run prevention side, the Guardians are leaning on Aaron Civale, who is pitching well in recent days. After a rough start in 2022, Civale has a 2.97 ERA in the last eight starts, allowing a .634 OPS in that stretch. Civale has a 2.00 ERA in his last four outings, and his numbers are far better at home than on the road this season. Cleveland's bullpen is also quite good, ranking in the top five of the AL in ERA and wins above replacement, and the Guardians average more than a strikeout per inning and more than three strikeouts per walk.

How to make Guardians vs. White Sox picks

SportsLine's model is leaning over on the total, projecting 7.9 combined runs, and it says one side of the money line has all the value. You can only get the MLB model's picks at SportsLine.

So who wins White Sox vs. Guardians? And which side has all the value? Visit SportsLine now to find out which side of you need to jump on, all from the model that has crushed its MLB picks, and find out.