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Robert Hanashiro / USA TODAY Sports

The Chicago White Sox look for their seventh consecutive victory when they host the slumping Kansas City Royals in the opening game of a doubleheader on Friday. Since a May 1 win at Minnesota, the Royals (16-20) have dropped 11 games in a row. The White Sox (22-13), meanwhile, have been trending in the opposite direction and are coming off three-game sweeps of both Kansas City and Minnesota. The Royals are 4-4 against the White Sox in their last eight games played at Chicago.

The seven-inning game will start at 3:10 p.m. ET from Guaranteed Rate Field in Chicago. Chicago is a -203 favorite on the money line (risk $203 to win $100) in the latest White Sox vs. Royals odds from William Hill Sportsbook, while the over-under for total runs scored is six. Before finalizing any Royals vs. White Sox picks, check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 44-31 on top-rated MLB money-line picks through six weeks, returning over $700. Anyone following it has seen huge rewards. 

Now, the model has dialed in on White Sox vs. Royals. You can visit SportsLine now to see the picks. Here are the MLB lines and trends for Royals vs. White Sox:

  • Royals vs. White Sox money line: Kansas City +183, Chicago -203
  • Royals vs. White Sox run line: Chicago -1.5 (+105)
  • Royals vs. White Sox over-under: 6 runs
  • KC: The under is 3-0-1 in the Royals' last four opening games of a doubleheader
  • CWS: The White Sox are 5-0 in their last five games on natural grass
Featured Game | Chicago White Sox vs. Kansas City Royals

Why you should back the White Sox

Chicago sends right-hander Lucas Giolito (2-3, 4.54 ERA) to the mound. He'll be backed by a lineup that is first in Major League Baseball in hitting. Offensively, shortstop Tim Anderson has been on fire. He enters the series with an eight-game hitting streak, including five multi-hit games, and is 13-for-36 (.361) with a double, one home run and six RBIs during that stretch. For the season, Anderson is hitting .315 with five homers and 15 RBIs. Against the Royals this year, he is 4-for-14 (.286) with a double. In 70 career games against the Royals, he is hitting .310 with 16 doubles, one triple, nine homers and 33 RBIs.

First baseman Jose Abreu has been heating up of late and is 11-for-28 (.393) during the White Sox's six-game win streak. He has three doubles, a triple, a homer and nine RBIs during that stretch. Since entering the big leagues, he has had a lot of success against Kansas City. In 118 career games, Abreu is batting .287 with 27 doubles, one triple, 21 homers and 66 RBIs vs. the Royals. He also has a .483 slugging percentage.

Why you should back the Royals

Right-hander Brad Keller (1-4, 7.31 ERA) gets the call as he tries to put an end to the team's recent woes. After getting rocked in his first two outings, Keller has been solid and has steadily lowered his ERA from a season-opening 40.50. In last Friday's start against Chicago, Keller took the loss despite allowing just three earned runs in six innings of work. He gave up five hits and a walk, while striking out six. In his April 26 start at Detroit, he scattered two runs on eight hits in picking up a 3-2 win. He walked two and struck out four.

Offensively, catcher Salvador Perez has been heating back up and is among the Royals' leaders with a .280 batting average. He has seven homers and 20 RBIs. In Thursday's loss at Detroit, Perez was 2-for-5 with an RBI. Last Friday against the White Sox, Perez was 4-for-4 with a double. He is hitting .250 this year against Chicago, and in 130 career games against the White Sox, is batting .258 with 24 doubles, two triples, 14 homers and 49 RBIs.

How to make Royals vs. White Sox picks

SportsLine's model is leaning over on the total, as the teams combine for 7.3 runs in the simulations, and it also says one side of the money line has all the value. You can only see the pick at SportsLine

So who wins Royals vs. White Sox? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model off to a hot start in 2021.