The Cleveland Cavaliers (19-12) travel to take on the Boston Celtics (15-16) in an Eastern Conference showdown on Wednesday night. The Cavaliers head into the matchup on a six-game win streak. The Celtics, meanwhile, were handed a loss in their last outing, falling to the Philadelphia 76ers 108-103. Boston has dominated this series in recent years, winning 10 of the last 13 meetings against Cleveland.

Tip-off is at 7:30 p.m. ET from TD Garden. Boston is favored by 6.5-points in the latest Cavaliers vs. Celtics odds from Caesars Sportsbook, while the over-under is 216.5. Before locking in any Celtics vs. Cavaliers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 10 of the 2021-22 NBA season on a stunning 46-23 roll on all top-rated NBA picks, returning almost $1,900. Anyone following it has seen huge returns.

Now, the model has set its sights on Celtics vs. Cavaliers and locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for Cavaliers vs. Celtics:

  • Cavaliers vs. Celtics spread: Boston -6.5
  • Cavaliers vs. Celtics over-under: 216.5 points
  • Cavaliers vs. Celtics money line: Boston -260, Cleveland +210
  • BOS: The Over is 4-1 in the last 5 meetings in Boston
  • CLE: The Cavaliers are 10-1 ATS in their last 11 road games
Featured Game | Boston Celtics vs. Cleveland Cavaliers

Why the Celtics can cover

Guard Jaylen Brown is averaging 21.8 points, 5.3 rebounds and 2.6 assists per game. The California product has scored 25-plus points in six games. His best outing came on Oct. 20 against the New York Knicks, recording 46 points, nine rebounds, six assists, and three steals. Brown had another strong showing in Boston's setback against Philadelphia on Monday, finishing with 30 points, five rebounds, four assists and two steals.

Marcus Smart is one of the best defensive guards in the NBA and is tied for second with two steals per game. Smart is also averaging 10.9 points, 3.9 boards, and 5.5 assists. Guard Dennis Schroder is third on the team with 16.3 points. He has the talent to go off in any matchup. On Nov. 12 against the Milwaukee Bucks, Schroder had a season-high 38 points, eight rebounds, and three assists.

Why the Cavaliers can cover

Guard Darius Garland is first on the team in points (19.1) and assists (7.3). Garland's game has taken a step forward in his third season. The Vanderbilt product has scored over 20 points 12 times this season, including back-to-back 30-point performances. On Dec. 3 against the Washington Wizards, he stuffed the stat sheet, finishing with 32 points, eight rebounds, and 10 assists. 

Forward Lauri Markkanen will have a bigger role in this contest with Allen and Mobley placed in health and safety protocols. Markkanen is averaging 13.7 points with five rebounds per game. The Arizona product has scored at least 20 points in five games thus far. Markkanen also stretches the floor and shoots 33 percent from 3-point range. 

How to make Cavaliers vs. Celtics picks

SportsLine's model is leaning under on the total, projecting 209 combined points. The model also says one side of the spread hits in almost 70 percent of simulations. You can only see the model's Celtics vs. Cavaliers picks at SportsLine.

So who wins Celtics vs. Cavaliers? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine now to see which side of the Cavaliers vs. Celtics spread you need to jump on Wednesday, all from the model that has crushed its NBA picks, and find out.