brock-purdy-49ers-usatsi.jpg
USATSI

The San Francisco 49ers (11-4) will travel to take on the Washington Commanders (4-11) on Sunday, and San Francisco will be looking to put a blowout loss at the hands of the Ravens aside. Washington hasn't won a game since the first week of November and hasn't won a game at home since the first week of the season against the Arizona Cardinals. However, these two teams have split their last four head-to-head matchups dating back to 2017, and the Commanders would love nothing more than to steal a win and spoil San Francisco's postseason home-field aspirations.

Kickoff is scheduled for 1 p.m. ET, and the game will be played at FedEx Field in Landover, Md. The latest Commanders vs. 49ers odds via the SportsLine consensus list San Francisco as a 14-point road favorite while the over-under is at 49.5. Before locking in any 49ers vs. Commanders picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Commanders and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for San Francisco vs. Washington:

  • Commanders vs. 49ers spread: 49ers -14
  • Commanders vs. 49ers over/under: 49.5 points
  • Commanders vs. 49ers money line: 49ers -983, Commanders +642
  • Commanders vs. 49ers picks: See picks at SportsLine
  • Commanders vs. 49ers live stream: fubo (try for free)

What to know about the 49ers

San Francisco had a six-game winning streak snapped last week against the Ravens, but the 49ers actually outgained Baltimore 429-343. They were ultimately undone by five turnovers, and they've lost all three games that they've lost the turnover battle this season.

However, they're still plus-eight in the turnover department this season, and they're taking on one of the most turnover-prone teams in the NFL this year. The Commanders have  27 giveaways and are minus-10 in differential, with 13 turnovers compared to only four takeaways during their current six-game losing streak. See which team to pick here.

What to know about the Commanders

Meanwhile, Washington is coming off its sixth straight loss. The Commanders fell just short of the Jets by a score of 30-28 last week. Washington almost overcame a 20-point deficit in the loss but fell behind for good on a 54-yard field goal from Greg Zuerlein with five seconds remaining. 

After their sixth straight loss, the Commanders opted to bench Sam Howell and named Jacoby Brissett the team's starting quarterback for the remainder of the regular season. Brissett, however, is out for Sunday with a hamstring injury, putting Howell back under center. The second-year quarterback has five games with 300-plus passing yards this season, and San Francisco allowed 241 passing yards and a pair of touchdowns thru the air last week. See which team to pick here.

How to make Commanders vs. 49ers picks

The model has simulated 49ers vs. Commanders 10,000 times and the results are in. The model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins Commanders vs. 49ers in Week 17, and which side of the spread hits in well over 50% of computer simulations? Visit SportsLine now to see which side of the spread to back, all from the model on a 178-129 roll on top-rated NFL picks, and find out.