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The NFC West champion San Francisco 49ers will try to complete the hat trick when they host the division-rival Seattle Seahawks in a 2023 NFL Super Wild Card Weekend game on Saturday. San Francisco (13-4), which is riding a 10-game winning streak, swept the two-game season series with Seattle after losing the previous four meetings between the clubs. The Seahawks (9-8) have lost four of their last five postseason contests, but defeated the 49ers in their only previous playoff encounter, as they posted a 23-17 home victory in the 2013 NFC Championship Game. It's the first game of the NFL playoffs 2023.

Kickoff from Levi's Stadium is set for 4:30 p.m. ET. San Francisco is a 9.5-point favorite in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, while the over/under for total points scored is 42. Before locking in any Seahawks vs. 49ers picks, make sure you check out the latest NFL predictions and betting advice from SportsLine's proven projection model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the Super Wild Card Weekend in the 2023 NFL playoffs on an incredible 161-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 15-6 roll on top-rated NFL picks since Week 7 of this season.

The model ranked in the Top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Seahawks on Saturday and just locked in its picks and NFL playoff predictions. You can visit SportsLine now to see the picks. Here are the NFL odds and trends for Seahawks vs. 49ers:

  • 49ers vs. Seahawks spread: San Francisco -9.5
  • 49ers vs. Seahawks over/under: 42 points 
  • 49ers vs. Seahawks money line: San Francisco -500, Seattle +400
  • SF: 49ers are 8-0 against the spread in their last eight games against division rivals 
  • SEA: Seahawks are 1-7 ATS in their last eight games
  • 49ers vs. Seahawks picks: See picks here

Why the 49ers can cover

Christian McCaffrey posted the third 1,000-yard season of his career, rushing for 1,139 overall to finish eighth in the NFL. The 26-year-old, who scored a touchdown in some fashion in six straight contests, is one of the biggest dual-threats in the league and led all running backs in 2022 with 741 receiving yards. McCaffrey had six catches for 101 yards and a TD in his only career playoff game in 2017 and can join Lenny Moore (two) and Tony Nathan (three) as the only running backs in NFL postseason history to reach triple-digit receiving yards in multiple contests.

The 49ers rank second in the league in scoring (30.5 points) and first in points allowed (14.4) during their current winning streak. Nick Bosa, who led the NFL with a career-high 18.5 sacks, including three versus Seattle, has done a strong job getting to the quarterback in the NFL playoffs during his career. The 25-year-old defensive end, who was the second overall pick in the 2019 NFL Draft, has recorded eight sacks in six postseason games and notched at least half-a-sack in each contest. See which team to pick here.

Why the Seahawks can cover

Geno Smith did his best to make Seattle fans forget about Wilson in his first season as a No. 1 quarterback since 2014 with the New York Jets. The 32-year-old set franchise single-season records with 572 attempts, 399 completions, 4,282 yards and an NFL-best 69.8 completion percentage. Smith also led the league with 15 touchdown passes thrown at least 15 yards downfield and was fourth with 30 overall scoring tosses.

DK Metcalf led the Seahawks with 1,048 receiving yards, while Tyler Lockett recorded his fourth straight 1,000-yard season with 1,033, marking the second time both wideouts amassed 1,000 yards in the same campaign (2020). Kenneth Walker III joined Curt Warner (1,449 in 1983) as the only rookies in Seattle history to rush for 1,000 yards, as he gained 1,050 in 15 games. See which team to pick here.

How to make 49ers vs. Seahawks picks

SportsLine's model is leaning Under the total, calling for 42 points. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's picks at SportsLine.

So who wins Seahawks vs. 49ers on Saturday? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Seahawks vs. 49ers spread to pick, all from the advanced model that is up well over $7,000 on its top-rated NFL picks, and find out.