Baker Mayfield and the Carolina Panthers (1-2) will take on Kyler Murray the Arizona Cardinals (1-2) on Sunday at Bank of America Stadium in Charlotte. The Panthers are coming off an impressive 22-14 win over the New Orleans Saints in Week 3, while the Cardinals are hoping to bounce back from a 20-12 loss to the defending Super Bowl champion Los Angeles Rams. The Panthers and Cardinals have met 19 times with Carolina holding a 14-5 advantage. Carolina All-Pro running back Christian McCaffrey (thigh) remains questionable for this matchup.

Kickoff is at 4:05 p.m. ET. Carolina is a 1-point favorite in the latest Panthers vs. Cardinals odds from Caesars Sportsbook, and the over/under is set at 43.5. Before making any Cardinals vs. Panthers picks, you'll want to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Panthers vs. Cardinals and just locked in its picks and NFL Week 4 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Cardinals vs. Panthers:

  • Panthers vs. Cardinals spread: Panthers -1
  • Panthers vs. Cardinals over/under: 43.5 points
  • Panthers vs. Cardinals picks: See picks here
Featured Game | Carolina Panthers vs. Arizona Cardinals

What you need to know about the Panthers

The Panthers beat the New Orleans Saints 22-14 this past Sunday. Carolina's WR Laviska Shenault Jr. filled up the stat sheet, catching two passes for one TD and 90 yards. Near the top of the highlight reel was Baker Mayfield's 67-yard TD bomb to Shenault Jr. in the fourth quarter.

The Panthers could be without McCaffrey, which would be a huge blow to their offense. The former Stanford standout is coming off back-to-back 100-yard rushing performances, and ranks fifth in the league in total rushing yards. If he is unable to play, Carolina will need Mayfield to produce at a level he has yet to in his three starts with the franchise. 

What you need to know about the Cardinals

Meanwhile, Arizona came up short against the Los Angeles Rams this past Sunday, falling 20-12. One thing working against Arizona was the run game. Top running back James Conner rushed for just 39 yards on 13 carries.

The Cardinals have made it clear they are looking to get Conner more involved to take some of the pressure off Murray. Arizona has rushed for a modest 316 yards through three games, but 65 of those yards were produced by Murray. Arizona is short-handed at wide receiver with A.J. Green (knee, out), Rondale Moore (hamstring, questionable), and Marquise Brown (foot, questionable) all battling injuries, and DeAndre Hopkins suspended for three more games. 

How to make Panthers vs. Cardinals picks

The model has simulated Panthers vs. Cardinals 10,000 times and the results are in. The model is leaning Over on the point total, and it also says one side of the spread has all the value. You can only see the model's pick at SportsLine.

So who wins Cardinals vs. Panthers? And which side of the spread has all the value? Visit SportsLine right now to find out which side of the Panthers vs. Cardinals spread you should be all over, all from the model on a 139-103 roll on its top-rated NFL picks, and find out.