An AFC showdown takes center stage on Sunday Night Football when the Tennessee Titans (5-2) go on the road to square off against the Kansas City Chiefs (5-2). Both teams are leading their respective divisions. Tennessee enters Sunday's showdown is on a five-game win streak, while Kansas City has won three of its last four outings. Titans quarterback Ryan Tannehill (ankle) is a game-time decision.

Kickoff is at 8:20 p.m. ET in Kansas City. Caesars Sportsbook lists Kansas City as a 13.5-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 45.5 in the latest Chiefs vs. Titans odds. Before you make any Titans vs. Chiefs picks, be sure to see the NFL predictions from SportsLine's resident Chiefs expert, Larry Hartstein.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2022 NFL season, he is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS (58 percent) and 8-3 on money-line plays last season for a profit of $1,552. 

In addition, Hartstein has gone 25-11 on his last 36 NFL picks involving the Chiefs, returning $1,265. Anybody who has been following him is way up.

Now, Hartstein has set his sights on Titans vs. Chiefs and just locked in his picks and Week 9 NFL predictions. You can head to SportsLine to see his picks. Here are several NFL odds and betting lines for Chiefs vs. Titans:

  • Chiefs vs. Titans spread: Chiefs -13.5
  • Chiefs vs. Titans over/under: 45.5 points
  • Chiefs vs. Titans money line: Kansas City -800, Tennessee +550
  • TEN: The Titans are 5-2 against the spread in their last seven meetings in Kansas City
  • KC: The Over is 7-2 in Chiefs' last nine games following an ATS win
  • Chiefs vs. Titans picks: See picks at SportsLine
Featured Game | Kansas City Chiefs vs. Tennessee Titans

Why the Chiefs can cover

Tight end Travis Kelce is a big and athletic pass-catcher in Kansas City's offense. Kelce is a tremendous run blocker with soft hands in the passing game. The seven-time Pro Bowl selection has been capable of consistently making big plays and is a regular red-zone threat. The Cincinnati product is tied for seventh in the NFL in receptions (47), tied for 10th in receiving yards (553), and tied for first in receiving touchdowns (7). 

Wide receiver Juju Smith-Schuster is starting to find his groove. Smith-Schuster has sure hands and excels on short and intermediate routes. The USC product utilizes his size and frame against defenders. He has caught 34 passes for 494 yards and two scores. The 2017 second-round pick has reeled in 100-plus yards in consecutive games. In his last contest, Smith-Schuster racked up 124 yards and a score. See which team to pick here.

Why the Titans can cover

Tennessee is stout upfront on the defensive line. The Titans quickly shed blocks and cause havoc in the backfield. They are second in the NFL in rushing yards allowed (89.1) with a league-low one rushing touchdown scored. Defensive lineman Denico Autry is a disruptive force who quickly sheds blocks as a both run stuffer and pass rusher.

Autry understands leverage fairly well and knows how to shoot the gaps. The Mississippi State product is second on the team in sacks (5) with four tackles for loss. Safety Kevin Byard is an effective player in all phases of the game. Byard shines in coverage due to his instincts and quickness. The two-time Pro Bowler has 45 total tackles and one interception. See which team to pick here.

How to make Chiefs vs. Titans picks

Hartstein has analyzed this matchup from every angle, and while we can tell you he's leaning Over on the point total, he has also discovered a crucial x-factor that makes one side of the spread a must-back. You can only find out what it is, and see the rest of Hartstein's picks, at SportsLine.

Who wins Chiefs vs. Titans on Sunday Night Football? And what critical factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Chiefs vs. Titans spread you should jump on, all from the top NFL expert who's an amazing 25-11 on picks involving Kansas City, and find out.