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After the Colts' listless showing last week versus the Patriots, Indy entered as six-point underdogs versus the Raiders in the Week 10 NFL odds. Then the Colts fired coach Frank Reich, replacing him with Jeff Saturday, who has no coaching experience above the high school level. How much did those transactions affect the NFL lines? The Colts are now four-point underdogs in the Week 10 NFL spreads from Caesars Sportsbook. The Colts and the Raiders have three against the spread wins this season, tied for the third-fewest in the league. The Raiders have blown three leads of 17-plus points this year, while Indy has replaced its starting QB, offensive coordinator and head coach in successive weeks. Before you make any Week 10 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He entered the 2022 NFL season 427-344 all-time on NFL picks (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS and 8-3 on money-line plays last season for a profit of $1,552. 

Hartstein also is 15-12 on his best bets this season, including 9-6 the past five weeks. Anyone who has consistently followed him is way up.

Hartstein has locked in his confident picks for three Week 10 games, and he has a parlay that would pay almost 6-1. You can only see his picks at SportsLine.

Top Week 10 NFL parlay picks

After closely studying all 14 Week 10 games, Hartstein loves the Dolphins to cover against the Browns. Browns quarterback Jacoby Brissett has just seven touchdown passes this season, which ranks 24th in the league. On the other hand, Dolphins quarterback Tua Tagovailoa leads the NFL in passer rating (115.9) and yards per attempt (9.2).

Behind Tagovailoa, Miami ranks second in the league in passing offense (293.6 yards per game) and fifth in total offense (380.4). "Even with corner Denzel Ward returning for the Browns following their bye, I don't see Cleveland slowing down Tyreek Hill, Jaylen Waddle and Mike McDaniel's innovative running game," Hartstein told SportsLine. You can see the rest of Hartstein's Week  NFL parlay picks here.

How to make Week 10 NFL parlays

Hartstein also has locked in two other against the spread picks to complete his parlay, including a play on a team facing a "struggling offense." You can find out who it is, and see the rest of Hartstein's NFL Week 10 parlay picks, at SportsLine

So which teams should you target in a three-way parlay that pays 6-1? And which team facing a "struggling offense" is a must-back? Visit SportsLine now to see Larry Hartstein's three-way parlay for Week 10, all from the expert who entered the season up more than $3,700, and find out.