North Carolina got off to a slow start this season, but an 8-1 record straight-up and against the spread in its last nine games has landed the Tar Heels in the 2022 March Madness Final Four. They have won and covered the spread in all four of their 2022 NCAA Tournament games thus far. Now, the second-seeded Tar Heels will try to win against No. 2 seed Duke at 8:49 p.m. ET on Saturday. North Carolina pulled off a 94-81 win as an 11-point underdog when these teams met in Duke head coach Mike Krzyzewski's final home game at Cameron Indoor Stadium.

The 2022 Final Four will begin with a matchup between No. 1 seed Kansas and No. 2 seed Villanova at 6:09 p.m. ET on Saturday. Can the Jayhawks build on their impressive second-half performance against Miami? Before locking in any Final Four 2022 picks or college basketball parlays, be sure to check out what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has crunched the numbers for Saturday's Final Four, with against-the-spread and over-under picks for both games. A successful parlay of these picks would pay 12-1. You can only see his NCAA Tournament picks at SportsLine

Top 2022 Final Four predictions, NCAA Tournament picks

One of the picks the model is backing for Saturday's Final Four 2022 parlay is over the total in Kansas vs. Villanova. Kansas is a strong offensive team, ranked No. 27 nationally in points per game (78.3). The Jayhawks are also very efficient, listed seventh in KenPom's offensive ratings.

They are coming off one of their best halves of the season, pouring in 47 points in the second half of their win over Miami. Villanova plays at a slow pace, but its efficient style and heavy dose of three-pointers create value on the over in this game. The Wildcats are No. 20 nationally in ratio of three-point attempts to total shot attempts.

SportsLine's model is projecting these teams to combine for 145 points, which would be more than enough to cash the over. The over is hitting in 80 percent of the model's simulations. 

How to make Final Four predictions, parlays for Saturday

The model also locked in spread and total picks for both games, and for one game it says one side of the spread cashes 60 percent of the time. Head to SportsLine to see his NCAA Tournament 2022 picks

Which college basketball picks should you target in a 12-1 parlay for Saturday's Final Four games? And which team covers in 60 percent of simulations? Visit SportsLine now to see the top 2022 NCAA Tournament parlays for Saturday, all from the model that has generated a profit of over $1,200 on its top-rated college basketball picks against the spread.