The Notre Dame Fighting Irish and the Louisville Cardinals are set to square off in an ACC matchup at 7 p.m. ET Wednesday at Purcell Pavilion at the Joyce Center. The Fighting Irish are 16-7 overall and 9-1 at home, while Louisville is 11-12 overall and 2-6 on the road. Notre Dame is now tied with Duke atop the ACC standings after the Blue Devils lost to Virginia on Monday. 

The Fighting Irish are favored by seven points in the latest Notre Dame vs. Louisville odds from Caesars Sportsbook, while the over-under is set at 135.5. Before entering any Louisville vs. Notre Dame picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Louisville. You can head to SportsLine to see its picks. Here are several college basketball odds for Louisville vs. Notre Dame:

  • Notre Dame vs. Louisville spread: Notre Dame -7
  • Notre Dame vs. Louisville over-under: 135.5 points
Featured Game | Notre Dame Fighting Irish vs. Louisville Cardinals

What you need to know about Notre Dame

Notre Dame has now won six of its last seven games following a 69-57 win at NC State last Saturday. Notre Dame held NC State to 20 of 67 shooting, which marked a season-best for its defense. The Fighting Irish find themselves tied with Duke for first place in the ACC, but the Blue Devils notched a 57-43 victory in the head-to-head meeting on Jan. 31. 

Notre Dame shot a season-high 15 of 23 from beyond the arc in an 82-70 win at Louisville last month, with four different players making at least three triples. Blake Wesley, who is one of three Notre Dame players averaging double digits, led the way with 22 points in the first meeting. The Fighting Irish have covered the spread in seven of their last eight home games against Louisville. 

What you need to know about Louisville

Louisville will be trying to record its first win since Jan. 19, as it has dropped five consecutive games. The Cardinals are playing under interim head coach Mike Pegues after the school parted ways with Chris Mack at the end of January. They took North Carolina to overtime last Tuesday before getting blown out in a 92-69 final at Syracuse on Saturday. 

Senior forward Malik Williams, who is the captain and leading scorer, is going to return from a three-game suspension on Wednesday night. His last game came against Duke on Jan. 29 when he recorded a double-double with 10 points and 12 rebounds. Louisville has won six of its last seven games against Notre Dame. 

How to make Notre Dame vs. Louisville picks

The model has simulated Notre Dame vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Louisville vs. Notre Dame? And which side covers over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.