One consistent challenge for college football bettors is figuring out what to do with huge lines. The Week 10 college football odds from William Hill Sportsbook, for example, list No. 19 Oklahoma at -38 against Kansas and Penn State at -25 against Maryland. Are those too many points to lay in conference matchups? Or are the Sooners and Nittany Lions set to roll by huge margins?

And how should you play tighter Week 10 college football lines such as No. 23 Michigan vs. No. 13 Indiana (+4) or No. 8 Florida vs. No. 5 Georgia (-3) in the SEC on CBS matchup at 3:30 p.m. ET? Before locking anything in for Saturday's action, be sure to see the top Week 10 college football expert picks, predictions and best bets from Barrett Sallee.

Sallee is a true insider -- a CBS Sports analyst, SiriusXM host, Heisman voter and consistently one of the top CBS Sports experts picking games against the spread -- and his best bets have helped bring in huge returns. He debuted with SportsLine in 2017 and has delivered in a big way, posting a winning record in his weekly college football best bets column since that point. 

He went 59-35-2 (63 percent, plus $2,037) on all his college football picks for SportsLine in 2019, and after sweeping them last week, he also enters Week 10 of the 2020 college football season on a 58-31 streak on his best bets since the start of last year. Anybody who has been following him is way up.

Now, he has turned his attention to the Week 10 college football odds from William Hill and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of 6-1. Get his top college football picks now

Top Week 10 college football expert predictions

One of Sallee's top college football picks for Week 10: He's backing No. 12 Oregon to cover the spread at home against Stanford in a Pac-12 battle at 7:30 p.m. ET on Saturday. There's been substantial line movement in this matchup as Oregon opened as a 13-point favorite, but is now down to -8.5. Sallee jumped on the Ducks in the midst of that movement because he's expecting them to perform well, even without quarterback Justin Herbert, who has moved on to the NFL.

Stanford was just 4-8 last year and struggled on both sides of the ball. The Cardinal ranked 108th nationally in scoring offense (21.7 ppg) and 80th in scoring defense (29.8 ppg). Oregon, meanwhile, had the ninth-best scoring defense in the nation last year, giving up just 16.5 points per game.

"Oregon is the new Stanford -- meaning that it thrives with an old-school, smashmouth style," Sallee told SportsLine. "The Ducks just do it out of the spread instead. CJ Verdell is rock solid at running back, the offensive line is monstrous and it is hard to find a reason to think that the Cardinal offense will have success against the Ducks defense."

Latest Odds: Oregon Ducks -11.5

How to make Week 10 college football picks 

Sallee has also found two other college football picks he's high on, including a strong play against a Top 25 team he believes is being overvalued. You can only see his picks at SportsLine.

What are the best bets for Week 10 of college football? And which ranked team should you completely fade? Visit SportsLine now to see Barrett Sallee's college football best bets, all from one of the top analysts in the nation who has crushed his picks for SportsLine.