The Week 6 college football odds from William Hill show multiple teams favored by three or more scores. No. 2 Alabama is listed at -24 against former offensive coordinator Lane Kiffin, who is now the head coach at Ole Miss. No. 5 Notre Dame, meanwhile, is laying 20.5 points at home against a struggling Florida State squad.

The largest of the Week 6 college football lines, however, is in the nonconference matchup between BYU and UTSA as the Cougars have the 35-point edge at home. How should you attack those spreads and others in your Week 6 college football bets? Before locking anything in for this weekend's action, be sure to see the top Week 6 college football expert picks, predictions and best bets from Barrett Sallee.

Sallee is a true insider -- a CBS Sports analyst, SiriusXM host, Heisman voter and consistently one of the top CBS Sports experts picking games against the spread -- and his best bets have helped bring in huge returns. He debuted with SportsLine in 2017 and has delivered in a big way, posting a winning record in his weekly college football best bets column since that point. 

He went 59-35-2 (63 percent, plus $2,037) on all his college football picks for SportsLine in 2019, and he also enters Week 6 of the 2020 college football season on a 49-28 streak on his best bets since the start of last year. Anybody who has been following him is way up.

Now, he has turned his attention to the Week 6 college football odds from William Hill and is sharing his top three best bets over at SportsLine. Get his top college football picks now

Top Week 6 college football expert predictions

One of Sallee's top college football picks for Week 6: Kentucky (-2 at William Hill) rolls to a cover against Mississippi State in a cross-division SEC matchup in Lexington at 7:30 p.m. ET on Saturday.

Mike Leach's Mississippi State squad looked unstoppable in its opener against LSU as quarterback K.J. Costello threw for over 600 yards and five touchdowns. But Arkansas slowed that attack last week with a lot of zone coverage and pulled off the 21-14 upset.

Sallee is looking for Kentucky to build on that strategy, while he also says Kentucky running backs Asim Rose and Chris Rodriguez Jr. "will run through the Bulldogs defense" as the Wildcats pick up their first win and cover of the season. 

How to make Week 6 college football picks 

Sallee has also found two other college football picks he's high on, including a strong play against a historic power he says "seems to be breaking more and more by the day." You can only see who he's backing at SportsLine.

What are the best bets for Week 6 of college football? And which traditional power should you fade? Visit SportsLine now to see Barrett Sallee's college football best bets, all from one of the top analysts in the nation who has crushed his picks for SportsLine.