Middleton was placed on the 15-day injured list Sunday, retroactive to Sept. 17, with a sprained left big toe.
Middleton has surrendered seven runs across his past three outings and will now be unavailable for at least the next couple weeks. The 29-year-old is eligible to return in early October for the final few games of the season, though Arizona could instead opt to shut him down.
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Cardinals' Keynan Middleton: Resumes throwing
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