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Yoshinobu Yamamoto makes his MLB debut when he and the Los Angeles Dodgers square off against the San Diego Padres in the second and final game of the 2024 Seoul Series on Thursday at Gocheok SkyDome in South Korea. One of the biggest free-agent prizes of the offseason, Yamamoto signed a 12-year, $325 million contract with the Dodgers. The 25-year-old righty is coming off a season in which he went 16-6 with a 1.21 ERA for the Orix Buffaloes in Japan. On Thursday he will face San Diego's Joe Musgrove as Los Angeles tries to sweep the two-game Seoul Series. The Dodgers won the first game of the 2024 MLB season on Wednesday, 5-2. 

First pitch is scheduled for 6:05 a.m. ET. Los Angeles is the -187 money line favorite (risk $187 to win $100) in the latest Dodgers vs. Padres odds via SportsLine consensus, while San Diego is a +156 underdog. The over/under for total runs scored is 8.5. Before making any Padres vs. Dodgers picks, check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It is coming off a profitable 93-74 season on top-rated MLB picks, and it excelled on top-rated run-line picks, going 18-6 (+766). Anybody following it has seen big returns.

Now, the model has set its sights on Dodgers vs. Padres and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's Seoul Series picks. Here are several MLB betting lines and trends for Padres vs. Dodgers:

  • Dodgers vs. Padres money line: Los Angeles -187, San Diego +156
  • Dodgers vs. Padres run line: Los Angeles -1.5 (+110), San Diego +1.5 (-131)
  • Dodgers vs. Padres over/under: 8.5 runs
  • LAD: Yoshinobu Yamamoto had a 1.21 ERA for the Orix Buffaloes in 2023
  • SD: Xander Bogaerts tied for eighth last year in the NL in hits (170)
  • Dodgers vs. Padres picks: See picks at SportsLine

Why you should back the Dodgers

Mookie Betts already has gotten off to a hot start this season. In Wednesday's season-opening win, the former American League MVP and seven-time All-Star went 2-for-4 with a walk and drove in a run. He is coming off a season in which he hit .307 with a career-high 39 homers and 107 RBI and finished second in the NL MVP voting.

Betts is one of several Dodgers who have had success against Musgrove. In 17 at-bats against Musgrove, Betts has a 1.005 OPS. Max Muncy (1.130 OPS in 26 at-bats) and Freddie Freeman (1.099 OPS in 26 at-bats) also have touched up Musgrove over their careers. See which team to back here.

Why you should back the Padres

Musgrove ended last season on a roll. Over his final 12 starts of last season, Musgrove went 9-1 with a 1.84 ERA and a 1.00 WHIP. The Padres went 9-3 over those 12 games. This year, the 31-year-old righty is coming off his best start of spring training, allowing just two hits and one run over 4.1 innings against Oakland.

The Padres have a bullpen to give the Dodgers' lefty-heavy lineup problems in the late innings. Because of an expanded roster for the Seoul Series, manager Mike Shildt has four lefties at his disposal to play mix-and-match. That bodes well against a Los Angeles lineup that on Wednesday featured six lefthanded batters. See which team to back here.

How to make Dodgers vs. Padres picks

SportsLine's model is leaning Over on the total, projecting 9.1 combined run. It also says one side of the money line has all the value. You can get the model's MLB picks only at SportsLine.

So who wins the second game of the 2024 MLB season and Padres vs. Dodgers, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that went 93-74 on its top-rated MLB picks last season, and find out.