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The New York Yankees (60-23) head to Fenway Park to take on the Boston Red Sox (45-38) in a fierce AL East rivalry matchup on Friday. New York is playing excellent baseball and owns the best record in the majors. Boston has also been solid and sits in second place in the AL East standings. Nestor Cortes (7-3, 2.44 ERA) will start for the Yankees. Connor Seabold (0-1, 8.31 ERA) takes the hill for Boston. Aaron Judge (lower body soreness) is set to return to action for New York,

First pitch is at 7:10 p.m. ET. Caesars Sportsbook lists New York as the -160 money-line favorite (risk $160 to win $100) in the latest Yankees vs. Red Sox odds, while Boston is a +135 underdog. The over-under for total runs scored is 9.5. Before making any Red Sox vs. Yankees picks, be sure to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 271-232 on top-rated MLB money-line picks since the start of the 2021 season, returning well over $500 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Yankees vs. Red Sox, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Red Sox vs. Yankees:

  • Yankees vs. Red Sox money line: New York -160, Boston +135
  • Yankees vs. Red Sox run line: New York -1.5 (+105)
  • Yankees vs. Red Sox over-under: 9.5 runs
  • NYY: 11-4 (+297) when Cortes stars 
  • BOS: Has returned +33 on the money line this season 
  • Yankees vs. Red Sox: See picks at SportsLine

Why you should back the Red Sox

Shortstop Xander Bogaerts is a gifted batter with outstanding plate coverage. Bogaerts can hit for a high average due to his awareness of the strike zone and pitch recognition skills. The three-time All-Star has a great arm and a solid frame. He's 12th in the MLB in batting average (.311) with seven homers and 34 RBIs.

Second baseman Trevor Story is a superb athlete with the ability to consistently get on base. Story has a compact swing that sprays all over the diamond. The two-time All-Star is leading the team in RBIs (54) as he hammered 14 home runs thus far. He's rolling into this matchup on a four-game hitting streak. 

Why you should back the Yankees

Outfielder Aaron Judge (lower-body soreness) was scratched Thursday, but will be back in the lineup tonight. Either way, the Yankees have a ton of bats to give Cortes run support. Second baseman Gleyber Torres is hitting .264 with 13 home runs and 35 RBIs. Giancarlo Stanton has 21 home runs and 54 RBIs on the season. 

Third baseman Josh Donaldson is a complete hitter with excellent patience and bat control. Donaldson has become a reliable defender in the corner with stellar instincts and reaction time. The three-time All-Star has eight home runs and 29 RBIs. He's belted a home run in back-to-back games, including a grand slam in Game 1 of the series on Thursday.

How to make Red Sox vs. Yankees picks

SportsLine's model is leaning over on the total, projecting 10.2 total runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Yankees vs. Red Sox? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.