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The Chicago Bears look to continue their improved play on defense when they host the Arizona Cardinals on Sunday afternoon. Chicago (5-8) scored a defensive touchdown in Week 15, but it wasn't enough to defeat Cleveland in a 20-17 loss. Arizona (3-11) fared poorly in a 45-29 defeat against San Francisco. The Cardinals won the teams' most recent matchup in 2021, a 33-22 victory in Chicago. Both teams are 6-7-1 against the spread in 2023.

Kickoff from Soldier Field is set for 4:25 p.m. ET. Chicago is a 4-point favorite in the latest Bears vs. Cardinals odds via SportsLine consensus, while the over/under is 43. Before making any Bears vs. Cardinals picks, you need to see the NFL predictions and betting advice from the advanced computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cardinals vs. Bears and just locked in its picks and NFL Week 16 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Bears vs. Cardinals:

  • Bears vs. Cardinals spread: Bears -4
  • Bears vs. Cardinals over/under: 43 points
  • Bears vs. Cardinals money line: Bears -199, Cardinals +164
  • Bears vs. Cardinals picks: See picks at SportsLine
  • Bears vs. Cardinals live stream: fubo (try for free)

Why the Cardinals can cover

The Cardinals have developed a potential star at the tight end position with the emergence of Trey McBride. The second-year player from Colorado State has taken a dominant role in Arizona's offense over the last two months, including a 10 catch, 102 yard performance against the 49ers in Week 15. For the season, he's caught 66 passes for 712 yards and two scores. McBride has seen at least nine targets in four of his last five games and should continue to be the top receiving option for quarterback Kyler Murray.

Murray's play since returning from a torn ACL suffered in late 2022 has been middling. While Arizona is 2-3 in his five starts, Arizona's starting QB has only accounted for seven total touchdowns in those games. Last week he threw for 211 yards on 26 of 39 passing with one touchdown pass and two interceptions. While he did rush for 49 yards on six attempts, he has another challenging test on Sunday against an improved Bears defense. See which team to pick here.

Why the Bears can cover

Chicago's defense has vastly improved with the presence of defensive end Montez Sweat, who was acquired from the Commanders at the trade deadline. The Bears have totaled 15 sacks in their last five games, including six by Sweat. Chicago's defensive score against Cleveland was their second all season, but the unit has generated an impressive 14 turnovers combined in their last four games.

Quarterback Justin Fields wasn't sharp against a stingy Browns defense, completing only 19 of 40 passes for 166 yards, with one touchdown and two interceptions. He added 30 yards rushing, which was the lowest ground output from Chicago's top QB in his last six games. Fields might be able to do more damage on the ground against the Cardinals, considering they rank second-to-last in rushing yards allowed (139.6). See which team to pick here.

How to make Cardinals vs. Bears picks

The model has simulated Cardinals vs. Bears 10,000 times and the results are in. It is leaning Over on the point total, and it also says one side of the spread hits more than 50% of the time. You can only see the model's Bears vs. Cardinals pick at SportsLine.

So who wins Bears vs. Cardinals on Sunday, and which side of the spread hits more than 50% of the time? Visit SportsLine right now to see which side of the Arizona vs. Chicago spread you should be all over Sunday, all from the model on a 178-129 roll on its top-rated NFL picks, and find out.