The New York Giants (1-4) and the Buffalo Bills (3-2) are set to square off on Sunday Night Football. This will be the 15th game in history between these teams and the series is tied 7-7. The last matchup took place in 2019 at MetLife Stadium where the Bills beat the Giants 28-14. New York hopes to return to the win column after dropping three straight games. Meanwhile, Buffalo has won three of its last four outings. Giants quarterback Daniel Jones will miss Sunday's showdown with a neck injury.
Kickoff from Highmark Stadium is set for 8:20 p.m. ET. The Bills are 15-point favorites in Bills vs. Giants odds, while the over/under for total points scored is 43.5. Before making any Giants vs. Bills picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer simulation model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Giants vs. Bills and just revealed its picks and predictions. You can visit SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Giants vs. Bills:
- Bills vs. Giants spread: Buffalo -15
- Bills vs. Giants Over/Under: 43.5 points
- Bills vs. Giants money line: Buffalo -1270, New York +767
- NYG: Under is 5-1 in the Giants' last six games
- BUF: Buffalo has gone over the total twice in three home games this year
- Bills vs. Giants picks: See picks at SportsLine
- Bills vs. Giants live stream: fubo (try for free)
Why Bills can cover
Buffalo's defense is ranked 12th in total defense (325.4) and ninth in passing defense (191.2). The defensive front plays a big factor in this unit. There are three players with at least three sacks on the year. Defensive end Leonard Floyd is a long and bendy rusher with an effective pass-rush plan. The Georgia product is leading the team in sacks (5.5) with 12 total tackles. He recorded two sacks in last week's loss to the Jaguars.
Defensive tackle Ed Oliver has a superb first step and great speed. Oliver consistently gets into the backfield to cause havoc. The Houston product is third on the team in total tackles (24) and first in tackles for loss (9). He also has four sacks. Last week, Oliver notched a season-high nine stops and one sack. Defensive end AJ Epenesa continues to be an impactful defender. Epenesa has totaled six total tackles, three sacks, and six pass deflections in 2023. See which team to pick here.
Why Giants can cover
New York's defensive front has some talented players. Defensive tackle Dexter Lawrence is a clog in the middle due to his ability to shut down run plays and command double teams. Lawrence is currently sixth on the team in total tackles (19) with a tackle for loss. In Week 3 against the 49ers, the Clemson product had a season-high seven total tackles.
Kayvon Thibodeaux is the best pass rusher on the team and he has good speed around the edge to go along with strong hands. The Oregon product leads the team in sacks (4) with 11 total tackles. He's logged a sack in three straight weeks. On Oct. 2 versus the Seahawks, Thibodeaux registered two total sacks. Cornerback Deonte Banks has played well through his first six career games. The 2023 first-round pick has secured 15 total stops and a team-high four pass breakups. See which team to pick here.
How to make Giants vs. Bills picks
SportsLine's model is leaning over the point total, projecting the teams to combine for 51 points. The model also says one side of the spread hits in nearly 60% of simulations. You can only set the model's pick at SportsLine.
So who wins Giants vs. Bills on Sunday Night Football, and which side of the spread hits in nearly 60% of simulations? Visit SportsLine now to see which side of the Giants vs. Bills spread you should jump on, all from the advanced model that is up more than $7,000 on top-rated NFL picks, and find out.
