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NFC West foes go toe to toe as Kyler Murray and the Arizona Cardinals host Brock Purdy and the San Francisco 49ers in Week 15 on CBS and Paramount+. The Cardinals are looking for a win coming out of their bye week as they sit at 3-10 with four games left in the season. They host a 49ers team that clinched a playoff berth in Week 14 and has won five in a row. You can stream the game in select markets on Paramount+, which you can now try free for the first 30 days when you use the promo code STREAMNFL (expires 12/31/23).

Kickoff from University of Phoenix Stadium in Glendale, AZ is 4:05 p.m. ET. The 49ers are 12-point favorites in the latest Cardinals vs. 49ers odds, and the over/under for total points scored is 48.5. Sunday's matchup can be seen live on CBS and streamed live on Paramount+ with their must-have Paramount+ with SHOWTIME plan, which you can now try free for 30 days with the promo code STREAMNFL.

Paramount+ is the only place to watch every minute of every NFL on CBS game this season. A subscription also gives you access to other sports content including the UEFA Champions League and Europa League, NWSL, Serie A, and countless movies and shows. You can get your first 30 days free with the promo code STREAMNFL, so sign up right here.

How to watch 49ers vs. Cardinals

  • Cardinals vs. 49ers date: Sunday, Dec. 17
  • Cardinals vs. 49ers time: 4:05 p.m. ET
  • Cardinals vs. 49ers TV channel: CBS 
  • Cardinals vs. 49ers streaming: Paramount+ (get 30 days free with promo code STREAMNFL)

Week 15 NFL picks for 49ers vs. Cardinals

Before tuning into Sunday's Cardinals vs. 49ers game, you need to see the NFL picks from SportsLine's advanced computer model. The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2023 NFL season on an incredible 176-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 30-21 roll on top-rated NFL picks since Week 7 of last season.

For Cardinals vs. 49ers, the model is picking San Francisco to cover the spread. Even with Murray back under center, the Cardinals do not have the weapons to compete with such a well-rounded 49ers team. Nick Bosa and the 49ers defense is ranked second in the entire league, while Purdy ranks third among QBs with 3,553 passing yards and Christian McCaffrey leads the league with 1,177 yards on the ground. Arizona managed a 24-10 win against the Pittsburgh Steelers before the bye week, but Mike Tomlin's team does not pose the same threats that Kyle Shanahan's does.

In addition, the 49ers are 11-2 against the spread in their last 13 games against a team from the NFC West. The Cardinals, meanwhile, are 0-6 against the spread in their last six games against a divisional opponent. You may be able to stream the game here.

How to watch, live stream the NFL on CBS

Now that you know what to pick, get ready to watch your live local NFL on CBS games on Paramount+ on any device you want. Don't forget you can now try Paramount+ free for the first 30 days with the promo code STREAMNFL.