An NFC West matchup will kick off Week 5 in the NFL as the Los Angeles Rams are set to enter Seattle for a matchup against the Seahawks. Both of these teams are coming into this "Thursday Night Football" head-to-head following inner-divisional matchups, that produced two different results. Seattle was able to edge out a road victory against the 49ers, while the Rams suffered their first loss of the season at the hands of the Arizona Cardinals. Of course, the NFC West is famous in recent years for being arguably the most competitive division in the NFL, so this is poised to be one heck of a start to this week's action. 

Below, we'll dive into all the different betting angles that this game has to offer. We'll take a look at how the lines have shifted leading up to this game as well as hand in our predictions for the contest. You can also find a handful of our favorite player props that you can wager on in this contest as well. 

All NFL odds via Caesars Sportsbook.

How to watch

Date: Thursday, Oct. 7 | Time: 8:20 p.m. ET
Location: Lumen Field (Seattle)
FOX | Stream: fuboTV (try for free)
Follow: CBS Sports App
Odds: Rams -2.5, O/U 54.5

Line movement

Latest Odds: Seattle Seahawks +2.5

The Rams opened as a slim 1-point favorite in this game against Seattle. After briefly moving to a pick'em on Sunday evening, L.A.'s advantage surged to 2.5 points on the eve of this head-to-head. 

The pick: Rams -2.5. While these teams have different records on the season, they are both 2-2 ATS entering Week 5. Seattle is famous for playing extremely well on Thursdays since Russell Wilson came to town, owning a 7-1-2 ATS record over his tenure. That said, this current iteration of the Seahawks doesn't stack up well with the Rams, who are largely considered to be the superior team. After losing to Cardinals last week, this is a strong "get-right" opportunity for a Los Angeles offense that will be going up against a Seahawks defense that is allowing the most total yards per game (444.5) in the NFL. The Seahawks' offense also has had a "Jekyll & Hyde" theme to them to start this season, which concerns me at less than a field goal. 

Key trend: Rams are 5-1 ATS in their last six games following a straight-up loss. 

Over/Under total

Currently, the total of this game is 54.5, which is the second-highest in all of Week 5 (Chiefs-Bills is sitting at 56.5). It originally opened at 53, but didn't take long to jolt up that extra 1.5 points, which has stood firm since Monday morning.  

The pick: Over 54.5. While Seattle is allowing the most total yards per game in the league, the Rams are not far off, allowing 396.8 yards of offense per game (sixth highest in the NFL). Each club is also allowing roughly 25 points per game and both are inside the top 10 in points scored. Points shouldn't be hard to come by here, especially with Stafford and Co. looking to rebound after totaling just 20 points a week ago. 

Key trend: Over is 4-1 in their last five meetings in Seattle. 

Matthew Stafford props

Matthew Stafford
LAR • QB • 9
View Profile
  • Passing touchdowns: 2.5 (Over +150, Under -180)
  • Passing yards: 301.5 (Over -115, Under -115)) 
  • Pass attempts: 38.5 (Over -125, Under -105)
  • Completions: 25.5 (Over -115, Under -115)
  • Rushing yards: 4.5 (Over -125, Under -105)
  • Longest pass completion: 39.5 (Over -115, Under -115)
  • Interceptions: 0.5 (Over +100, Under -130)

The two Stafford props that stand out the most are the Over on his 25.5 completions and the Over 301.5 passing yards. Seattle has allowed the seventh-most completions through the first month of the season at a 26.2 completions-per-game average. I expect the Rams to be throwing quite a bit in this game and Stafford has gone over this total in two straight games coming into Week 5. That passing yards total is high, but Stafford has eclipsed this number twice already and Seattle is allowing 292.5 passing yards per game, which is flirting right around where the Rams QB will need to jump over. 

Russell Wilson props

Russell Wilson
DEN • QB • 3
View Profile
  • Passing touchdowns: 1.5 (Over -160, Under +130)
  • Passing yards: 272.5 (Over -115, Under -115)
  • Pass attempts: 35.5 (Over +115, Under -145)
  • Rushing yards: 21.5 (Over -115, Under -115)
  • Completions: 24.5 (Over -120, Under -110)
  • Longest pass completion: 37.5 (Over -110, Under -120)
  • Interceptions: 0.5 (Over +140, Under -170)

I also love the Over on Wilson's 24.5 completions. The Rams have allowed the second-most completions in the league, giving them a per-game average of 29 entering Week 5. While Wilson has yet to go over this number this season, Chris Carson (neck) being held out or limited for this game could bump his passing attempts higher. 

Player props to consider

Robert Woods receiving yards: Under 60.5 (-115). Woods has been a non-factor in the Rams' offense this season. He's gone over this prop once, but his role is severely limited with Stafford not looking his way as often as many predicted prior to the season. 

Van Jefferson receptions: Over 3.5 (-115). Jefferson's role has continued to increase as the season has gone on, seeing six targets in back-to-back games. Over that stretch, he's logged 10 catches, including all six of his targets last week.

Cooper Kupp receiving yards: Over 85.5 (-115). Kupp is seeing double-digit targets (11.5 per game) from Stafford on a weekly basis. With that kind of volume, it's hard to fade any receiving prop for him right now.