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The Dallas Cowboys will try to take advantage of a struggling opponent when they visit the Tennessee Titans on Thursday Night Football. Dallas (11-4) has won five of its last six overall contests and still has a chance to repeat as NFC East champion since it trails first-place Philadelphia by two games with two remaining. But the Cowboys are just 3-3 on the road this season, losing three of their last four away from home. Tennessee (7-8), which is tied with Jacksonville for first in the AFC South, is in the midst of the longest losing streak of head coach Mike Vrabel's tenure, as last week's 19-14 setback against Houston was its fifth consecutive defeat. Derrick Henry (hip) and Tony Pollard (thigh) are both inactive.

Kickoff from Nissan Stadium in Nashville is set for 8:15 p.m. ET. Dallas is a 14-point favorite in the latest Titans vs. Cowboys odds from Caesars Sportsbook, while the over/under for total points scored is 40. Before making any Cowboys vs. Titans picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 of the 2022 NFL season on an incredible 158-113 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cowboys vs. Titans and just locked in its picks and Thursday Night Football predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Titans vs. Cowboys: 

  • Titans vs. Cowboys spread: Dallas -14
  • Titans vs. Cowboys over/under: 40 points 
  • Titans vs. Cowboys money line: Dallas -900, Tennessee +600
  • DAL: Cowboys are 11-4 against the spread in their last 15 road games 
  • TEN: Titans are 0-4-1 against the spread in their last five contests 
  • Titans vs. Cowboys picks: See picks at SportsLine

Why the Cowboys can cover

Dallas ranks sixth with an average of 20.2 points allowed this season, but it has surrendered a total of 97 over its last three games. The defense should get back on track against a Tennessee team that is 27th in the league in scoring (17.9 points) and has yet to record more than 27 points in a contest this year. The Titans have averaged 15.2 points during their losing streak and are missing No. 1 quarterback Ryan Tannehill (ankle surgery).

The Cowboys lead the NFL with a plus-12 turnover differential and are third with 49 sacks, which could make for a long night for expected Titans signal-caller Josh Dobbs. The rookie has thrown three interceptions and been sacked 10 times in his three starts this season and has yet to make his first career touchdown pass. Dallas is tied for fifth in picks (14), with rookie cornerback DaRon Bland among the league leaders with five, including one in each of his last two games. See which team to pick here.

Why the Titans can cover

Dallas is 22nd in the NFL against the run, allowing an average of 130 yards per game, so being without Derrick Henry would normally be a huge blow to the Titans. However, it will allow them to take a good look at Hassan Haskins, who was selected in the fourth round of the 2022 NFL Draft after rushing for 1,327 yards and 20 touchdowns at the University of Michigan last year. The 23-year-old has made only two carries in 11 games since leading Tennessee with 37 yards on nine attempts against Buffalo in Week 2.

While the Cowboys are seventh in the league in rushing (143.1 yards), they will reportedly be without Tony Pollard, who leads the team with 988 yards but is questionable with a thigh injury. That bodes well for a Tennessee defense that ranks second with an average of 80.1 rushing yards allowed. Dallas is third in scoring (28.9 points), but the Titans are surrendering 20.8 per game and have permitted more than 20 only twice in their last 12 contests. See which team to pick here.

How to make Cowboys vs. Titans picks on TNF

SportsLine's model is leaning Over the point total, calling for 42 combined points. The model also says one side of the spread cashes in over 50% of simulations. You can only see the model's TNF picks at SportsLine.

So who wins Cowboys vs. Titans on Thursday Night Football? And which side of the spread cashes over 50% of the time? Visit SportsLine now to see which side of the Cowboys vs. Titans spread you need to jump on, all from the model on a 158-113 roll on NFL picks, and find out.