The Philadelphia Eagles and Minnesota Vikings opened the 2022 NFL schedule with Week 1 victories. On Monday Night Football, the Eagles and Vikings meet at Lincoln Financial Field, with both teams seeking their first 2-0 start since 2016. Philadelphia was 9-8 last season, making the postseason, and beat the Detroit Lions by a 38-35 margin in the opener. Minnesota was 8-9 in 2021 and toppled the Green Bay Packers by 16 points last week.

Kickoff is at 8:30 p.m. ET in Philadelphia. Caesars Sportsbook lists the Eagles as 2.5-point home favorites, while the over/under, or total number of points Vegas thinks will be scored, is 50.5 in the latest Vikings vs. Eagles odds. Before you make any Eagles vs. Vikings picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer simulation model.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Vikings vs. Eagles and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model's picks. Now, here are several NFL odds and betting lines for Vikings vs. Eagles:

  • Vikings vs. Eagles spread: Eagles -2.5
  • Vikings vs. Eagles over/under: 50.5 points 
  • Vikings vs. Eagles money line: Eagles -135, Vikings +115
  • MIN: Vikings are 10-8 against the spread in the last 18 games 
  • PHI: Eagles are 8-10-1 against the spread in the last 19 games 
  • Vikings vs. Eagles picks: See picks here
Featured Game | Philadelphia Eagles vs. Minnesota Vikings

Why the Vikings can cover

Vikings quarterback Kirk Cousins has enjoyed success against the Eagles in his career. Cousins is 6-3 all-time against Philadelphia, including a 2-0 mark with the Vikings. In those nine outings, Cousins is averaging 306.2 passing yards per game with 21 touchdowns, six interceptions, and a 104.9 passer rating. Cousins also played well a week ago, racking up 277 yards and two touchdowns in the opener, and has one of the best completion rates (67.8%) in the NFL over the last eight seasons.

Cousins is a three-time Pro Bowler who benefits from two elite skill players in Justin Jefferson and Dalvin Cook. No player has more receiving yards (3,200) than Jefferson since the start of the 2020 season, including 184 yards and two touchdown receptions last week. Jefferson has the second-most receiving yards of any player in NFL history over the first 34 games of a career, and Cook is also electric. The three-time Pro Bowl running back exceeded 100 total yards in the opener and finished in the top five in rushing yards and top 10 in yards per carry during the 2021 season.

Why the Eagles can cover

On defense, Philadelphia scuffled a bit in Week 1, but the Eagles were in the top 10 of the NFL in total defense and rushing defense last season. Opponents averaged only 4.0 yards per carry against the Eagles in 2021, a top-six mark in the league, and Philadelphia's defensive two-deep is even better on paper in 2022. On the offensive side, the Eagles generated 455 total yards, 27 first downs, and 38 points in Week 1, with elite marks on the ground.

Philadelphia led the NFL in rushing yards and rushing touchdowns last season, and the Eagles produced 216 rushing yards and four rushing touchdowns against Detroit a week ago. Jalen Hurts is a dual-threat standout at the quarterback position, producing 4,306 passing yards and 1,146 rushing yards in 20 career starts. Hurts has the second-most rushing yards all-time by a quarterback in his first 20 starts and is the only player in NFL history with at least 4,000 passing yards and 1,000 rushing yards over a 20-start stretch to begin a career.

How to make Vikings vs. Eagles picks

SportsLine's model is leaning Over on the total, with both teams projected to run for well over 100 yards. The model also says one side of the spread cashes in over 50% of simulations. You can only see the model's MNF pick at SportsLine.

So who wins Eagles vs. Vikings on Monday Night Football? And which side of the spread cashes in over 50% of simulations? Visit SportsLine now to see which side of the Eagles vs. Vikings spread you need to jump on Monday, all from the model that's 139-98 on NFL picks, and find out.