Paolo Banchero Duke Blue Devils Basketball
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The No. 6 Duke Blue Devils and the Florida State Seminoles are set to square off in an ACC matchup at 9 p.m. ET on Tuesday at the Donald L. Tucker Center. Florida State is 10-5 overall and 6-1 at home, while the Blue Devils are 14-2 overall and 1-1 on the road. This will be Duke's first game outside the state of North Carolina since November. 

The Blue Devils are favored by five points in the latest Florida State vs. Duke odds from Caesars Sportsbook, while the over-under is set at 145. Before entering any Duke vs. Florida State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on FSU vs. Duke. You can head to SportsLine to see its picks. Here are several college basketball odds for Duke vs. FSU:

  • Florida State vs. Duke spread: Duke -5
  • Florida State vs. Duke over-under: 145 points

What you need to know about Florida State

Florida State will be confident entering this game, as it is riding a three-game winning streak following a 76-71 decision at Syracuse over the weekend. The Seminoles recorded wins over Louisville and Miami in their previous two games. They were without leading rebounder Malik Osborne on Saturday due to an ankle injury and he is not expected to play on Tuesday. 

Osborne is also the team's second-leading scorer, averaging 11.1 points. The Seminoles will need even more from sophomore guard Caleb Mills, who is putting up a team-best 13.0 points per game. Florida State has been dominant at home, winning 14 of its last 15 games. 

What you need to know about Duke

Duke has bounced back from a shocking loss against Miami with consecutive wins over Wake Forest and NC State. The Blue Devils scored a season-high 58 points in the paint in their win over the Wolfpack on Saturday. They have now played four games since returning from a COVID-19 pause and will be leaving their home state for the first time since November. 

Freshman forward Paolo Banchero leads Duke with 17.9 points and 7.4 rebounds per game. Forward Wendell Moore Jr. and guard Trevor Keels are both in double figures as well. Duke has won four of its last five road games at Florida State. 

How to make Florida State vs. Duke picks

The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Duke vs. Florida State? And which side covers over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.