Christian McCaffrey owners rejoiced to see their first-round pick back in their Fantasy football lineups a week ago. He produced in a winning way, with 151 yards from scrimmage and two touchdowns against the Chiefs. However, McCaffrey will miss Week 10 with a shoulder injury, which will once again force owners to seek alternative options with their Fantasy football picks. Meanwhile, Kenyan Drake (ankle), Miles Sanders (knee) and Nick Chubb (knee) are all expected to return from injury, but where should each one be in your Week 10 Fantasy football rankings?

A reliable set of rankings can help you work the Fantasy football waiver wire and trade block to ensure that you have the depth to withstand plenty of Fantasy football injuries. Before you lock in your lineups, be sure to check out the latest Week 10 Fantasy football rankings from the proven computer model at SportsLine. 

When it comes to ranking players, their model beat human experts in Fantasy football last season when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Last week, the model was extremely high on Cardinals quarterback Kyler Murray, saying he'd finish as the No. 2 overall QB. The result: Murray completed 21 of 26 pass attempts for 283 yards and three touchdowns. He also recorded 11 carries for 106 yards and an additional score. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 10 of the 2020 NFL season. Head to SportsLine now to see them. 

Top Fantasy football picks for Week 10

One player the model is extremely high on this week: Bills running back Zack Moss. The rookie out of Utah was expected to compete with Devin Singletary for touches this season, but he got off to a slow start because he missed three weeks with a toe sprain. However, since his Week 6 return, his snap count has gradually trended upward while Singletary's has fallen off. 

Moss has now out-snapped Singletary the last two games and produced 129 yards and three touchdowns on 25 touches. He creates 1.8 yards per touch after first missed tackle, the seventh-best among all running backs. Against an Arizona defense that ranks 24th in yards allowed per carry (4.6), you can expect a sizable workload for Moss. That's why the model ranks him as a top-20 running back for Week 10, a rock-solid RB2.

A massive shocker: Buccaneers wide receiver Mike Evans, who's tied for fourth in the league with seven touchdown receptions, stumbles big-time and doesn't even crack the top 25 at his position. Evans and the entire Tampa Bay offense struggled mightily against the Saints, scoring just three points in a lopsided 38-3 loss. 

Evans finished with four receptions for 64 yards in last Sunday's loss to New Orleans. He's failed to eclipse 70 receiving yards in five consecutive games and scored just two touchdowns during that stretch.

With the addition of Antonio Brown to Tampa Bay's crowded receiving corps, Evans remains touchdown-dependent given the fact that he's averaging just 4.25 targets per game in his last four outings. He's a player to consider putting on your bench in Week 10. 

How to set your Week 10 Fantasy football rankings

The model is also calling for a surprising quarterback you aren't even thinking about to finish in the top 10 of its Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. You can see who it is here.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 10 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that out-performed experts big-time last season.