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The Fantasy football playoffs are in full swing, which means a reliable set of Week 16 Fantasy football rankings will be paramount to advance to the championship round. Players like Cooper Kupp, Justin Jefferson and Patrick Mahomes are obvious starts, regardless of matchup. But fringe players like Chuba Hubbard, Russell Gage and Tyler Boyd bring tougher Fantasy football sit-start decisions.

A reliable set of Week 16 Fantasy football rankings can help you make those tough calls. Who can you bank on for your Week 16 Fantasy football lineups, and which players should you completely avoid? Before locking in any Week 16 Fantasy football picks, be sure to check out the Week 16 Fantasy football predictions from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home emptyhanded.

Last week, the model was extremely high on Lions running back Craig Reynolds, ranking him as a top-30 running back and a player you should have been giving serious FLEX consideration. The result: Reynolds rushed for 112 yards in a stunning upset win over the Cardinals. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 16 of the 2021 NFL season. Head to SportsLine now to see them.

Top Week 16 Fantasy football picks 

One player the model is high on this week: Seahawks running back Rashaad Penny. He led Seattle with 11 rush attempts against the Rams last week, finishing with 39 yards in the 20-10 loss.

Despite averaging just 3.5 yards per carry against the Rams, Penny is expected to bounce back against a Chicago defense that is giving up 120.9 rushing yards per game this season. The 2018 first-round pick has proven capable of producing big numbers. In fact, Penny racked up 137 rushing yards and two touchdowns in Seattle's Dec. 12 victory over the Texans. He's also recorded at least 10 carries in his last three games, which gives him ample opportunity to provide value. Lock him in your Week 16 Fantasy football lineups and look for a big return against the Bears on Sunday. 

And a massive shocker: Bears running back David Montgomery, who was started in 91 percent of CBS Sports Fantasy football leagues last week, stumbles big-time and doesn't even crack the top 20 at his position in Week 16. Despite being the center of attention in an offense that doesn't do much well, Montgomery has put up solid numbers when healthy, with 884 scrimmage yards and four scores in 10 games.

However, he's coming off a week in which he only managed 83 yards on 23 touches as the Bears squandered numerous possessions that started in their own territory. Now, he'll take on a Seahawks run defense that ranks second in the NFL in yards allowed per carry (3.8).

How to set Week 16 Fantasy football rankings

The model is also calling for an under-the-radar quarterback to finish in the top 10 of its Fantasy football rankings. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 16 Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has out-performed experts big-time.