MLB: Milwaukee Brewers at San Francisco Giants

Angels two-way star Shohei Ohtani can strengthen his case to win the American League MVP award when he faces the Seattle Mariners on Monday at Angel Stadium. The reigning AL MVP, Ohtani (10-7, 2.68 ERA) ranks fifth in the AL in home runs (26) and RBI (68). He is 1-0 against the Mariners this season but has struggled at the plate (.143 batting average, .443 OPS) against Seattle. Caesars Sportsbook lists both Los Angeles and Seattle at -110 in the latest Angels vs. Mariners odds.

First pitch is set for 9:38 p.m. ET from Anaheim, Calif. The game is one of 14 on the MLB schedule for Monday. Elsewhere in the majors, the Mets and Braves open a key four-game series in Atlanta, and the Guardians and Tigers play a doubleheader in Cleveland. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is a 300-260 on top-rated MLB money-line picks since the start of the 2021 season. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Monday. They all involve games at 6:40 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of well over 14-1. You can see the model's MLB picks only at SportsLine

Top MLB picks today

The model, which ran 10,000 simulations on each of Monday's games, likes Seattle (-110) to beat the Los Angeles Angels. The Mariners (62-54), who haven't made the playoffs since the 2001 season, are positioned to end the longest active postseason drought in the country's four major sports leagues. They are second among AL wild card teams; three make the playoffs. Meanwhile, Los Angeles (51-64) is set to miss the postseason for the eighth straight year.

Luis Castillo has pitched lights-out this summer. In his last seven starts, the former Reds ace has given up just nine earned runs in 47.2 innings (1.70 ERA). His team is a perfect 7-0 in those starts. In addition, he is coming off arguably his best start of the season, limiting the powerful Yankees lineup to just three hits in eight scoreless innings. See who else to back right here.

Featured Game | Los Angeles Angels vs. Seattle Mariners

How to make MLB picks and parlays for Monday

The model also locked in three other best bets for Monday, including a play on a big AL underdog. You can see the model's MLB Monday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of well over 14-1? And what underdog does the model like on Monday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 300-260 run on top-rated MLB money-line picks since the start of 2021.