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Reigning AL MVP Shohei Ohtani takes the mound on Wednesday when he and the Los Angeles Angels take on the Texas Rangers at Globe Life Field in Arlington, Texas. After a bit of a slow start, the two-way Angels star has turned things around. As a pitcher, Ohtani is 3-2 with a 2.78 ERA. As a hitter, he has eight homers and 27 RBI and is batting .255. On Wednesday, he squares off against the Rangers' Dane Dunning (1-2, 4.06 ERA). Los Angeles is a -180 money-line favorite in the latest Angels vs. Rangers odds from Caesars Sportsbook, while Texas is a +160 underdog. 

First pitch is set for 8:05 p.m. ET. The game is one of 15 on the MLB schedule on Wednesday. Elsewhere in the majors, the Giants' Logan Webb (5-1) goes for his major-league leading sixth win of the season, and Mets ace and St. Louis-area native Max Scherzer faces his hometown Cardinals. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and is off to a sizzling start to the 2022 season. It's on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen some huge returns.

Now, the model has locked in four confident MLB best bets for Wednesday. All the games occur at 6:10 p.m. ET or later, so there's still plenty of time to make these MLB picks. If you successfully parlay the picks, you'd be looking at a payout of 15-1. You can only see the model's MLB picks at SportsLine.

Top MLB picks today

The model, which simulated every game on Wednesday's schedule 10,000 times, is high on the Cleveland Guardians (-135) to beat the Cincinnati Reds at 6:10 p.m. ET (see tickets at StubHub). Despite losing 5-4 in 10 innings to the Reds on Tuesday, the Guardians have dominated their interstate rivals recently. Cleveland has won four of the last five meetings between the teams, including two of three this season.

In addition, the Guardians face a starter, Tyler Mahle (2-4, 5.89 ERA), who has struggled this season. Over his last seven starts, Mahle is 1-4 with a 6.82 ERA. He also has a 6.50 ERA on the road. In addition, Mahle is 0-2 with a 6.61 ERA in his career against Cleveland. 

Featured Game | Cleveland Guardians vs. Cincinnati Reds

How to make MLB picks and parlays for Wednesday

The model also locked in three other best bets for Wednesday, including a must-see play an an underdog that wins outright over 50 percent of the time. You can see the model's MLB best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of 15-1? And what underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 33-25 roll on top-rated MLB money-line picks through six weeks.