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The Cleveland Guardians are hoping to continue their solid pitching when they open the American League Division Series against the New York Yankees on Tuesday. The Guardians (92-70), champions of the AL Central Division by 11 games over the Chicago White Sox, allowed just one run in the two-game Wild Card Series with Tampa Bay, including zero runs in a 15-inning marathon victory in the series clincher. The Yankees (99-63), meanwhile, cruised to the AL East title, their first in three years. The 2022 MLB playoffs will be New York's sixth consecutive postseason appearance and 24th since the 1995 season. Gerrit Cole (13-8, 3.50 ERA) will start for the Yankees, with Cal Quantrill (15-5, 3.38 ERA) going for Cleveland.

The game from Yankee Stadium is slated to begin at 7:37 p.m. ET, and both teams sport top-notch pitching staffs. The Yankees finished the regular-season with the third-best ERA in MLB at 3.30, while the Guardians were tied for fifth with a 3.46 ERA. New York is a -210 favorite on the money line in the latest Guardians vs. Yankees odds from Caesars Sportsbook, while the over-under for total runs scored is 6.5. Before making any Yankees vs. Guardians picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it enters the divisional round on a 20-11 roll on top-rated MLB money-line picks, returning more than $600. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has set its sights on Yankees vs. Guardians, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Yankees vs. Guardians:

  • Yankees vs. Guardians money line: New York -210, Cleveland +175
  • Yankees vs. Guardians over/under: 6.5 runs
  • Yankees vs. Guardians run line: New York -1.5 (+110)
  • CLE: The Guardians are 17-4 in their last 21 games against a right-handed starter
  • NYY: The Yankees are 54-18 in their last 72 games against an AL Central Division opponent
  • Yankees vs. Guardians picks: See picks here

Why you should back the Yankees

New York is a staple in the MLB playoffs and is looking to reach its first World Series since the 2009 season, when the Yankees defeated the Philadelphia Phillies in six games. Right fielder Aaron Judge continues to set the pace for Yankees hitters, batting .311 with an American League record 62 homers, 131 RBI and 133 runs scored. In six games against the Guardians this year, he has two doubles, two homers and three RBI. He also walked five times and stole one base.

First baseman Anthony Rizzo also provides some pop to the New York lineup. Although he hit just .224 on the season, he hit 32 homers and drove in 75 runs in 130 games. He scored 77 runs, walked 58 times and had a slugging percentage of .480. In five games against the Guardians, Rizzo batted .300 with a double, two homers and three RBI.

Why you should back the Guardians

Cleveland will send right-hander Quantrill (15-5, 3.38 ERA) to the hill. In his last start on Oct. 4 against Kansas City, he allowed just one earned run on four hits in five innings to earn the win. He did not walk a batter and struck out four. Quantrill has won his last 11 decisions and had a no-decision in a 5-4 loss to the Yankees on April 23. In that game, Quantrill allowed three earned runs in 6.1 innings, walking three and striking out two.

Helping lead the Guardians offense is center fielder Steven Kwan, who is among the team's top hitters. In 147 games this season, Kwan batted .298 with six homers, 52 RBI and 89 runs scored. He is looking for his first hit of the postseason after hitting in eight of the final nine regular-season games. In six games against New York this year, he had four hits, including a double, with one RBI.

How to make Yankees vs. Guardians picks

SportsLine's model is leaning over on the total and it says one side of the money line has all the value. You can only get the MLB model's picks at SportsLine.

So who wins Yankees vs. Guardians? And which side has all the value? Visit SportsLine now to find out which side of you need to jump on, all from the model that has crushed its MLB picks, and find out.