After missing nearly all of the previous two seasons with arm issues, Jameson Taillon was acquired from Pittsburgh in January 2021 and recorded eight victories in his first campaign with the New York Yankees. The 30-year-old right-hander already has reached that number in just 14 starts this year, winning eight consecutive decisions after suffering a hard-luck loss in his season debut. Taillon looks to extend his streak and help his team complete a three-game sweep when the major league-leading Yankees host the Oakland Athletics on Wednesday afternoon.

First pitch at Yankee Stadium is set for 1:05 p.m. ET. New York is the -300 money-line favorite (risk $300 to win $100) in the latest Yankees vs. Athletics odds from Caesars Sportsbook, while Oakland is the +250 underdog. The over/under for total runs scored is 8.5. Before making any Athletics vs. Yankees picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 59-51 run on top-rated MLB money-line picks through 12 weeks. This is the same model that pegged the 2021 Atlanta Braves as one of three best bets to win it all last season at +1000. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Yankees vs. Athletics, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Athletics vs. Yankees:

  • Yankees vs. Athletics money line: New York -300, Oakland +250
  • Yankees vs. Athletics over-under: 8.5 runs
  • Yankees vs. Athletics run line: New York -1.5 (-145)
  • NYY: The Yankees have recorded the best 75-game start in MLB since the 2001 Seattle Mariners (56-19)
  • OAK: The A's own the worst batting average in the league at .210
Featured Game | New York Yankees vs. Oakland Athletics

Why you should back the Yankees

New York owns the best record in the majors at 55-20 and has been dominant in nearly every facet of the game. The Yankees lead all teams in homers (124), RBI (358) and runs scored (378) while ranking a close second behind Toronto in OPS (.757). The club also has performed exceptionally well on the mound, ranking first in ERA (2.93), WHIP (1.07) and opponents' batting average (.213).

Oakland has done a good job keeping Aaron Judge under control as the slugger has gone just 1-for-8 over the first two games of the series. But the 30-year-old leads the majors with 28 home runs and is second in the American League with 57 RBI, so he won't be kept under control for long. Gleyber Torres has recaptured the form that made him an All-Star in 2018 and 2019 as he's already launched 13 home runs. That tops what he put up over the last two seasons combined (12), and his defense is also elite as well as he ranks in the top 10 in the AL in defensive WAR (1.0).

Why you should back the Athletics

Oakland has recorded only 25 wins in 2022, but 17 of them have come on the road. Cole Irvin (2-5, 3.29 ERA) has pitched much better this season than his record indicates, as he has given up three runs or fewer in 10 of his 12 outings. The 28-year-old left-hander has gone 0-4 over eight starts since picking up the victory against Texas on Apr. 24 but actually has lowered his ERA from 3.32 to 3.29 in that span. Irvin hasn't received much offensive support as the Athletics have scored fewer than four runs in nine of his turns, including each of his last four starts and one of his two victories.

Elvis Andrus has been Oakland's top producer at the plate through the first two games of the series. The 33-year-old shortstop recorded two of the Athletics' six hits in the opener, including a three-run double that gave the team a 5-1 lead, and delivered a two-out RBI single in the ninth inning on Tuesday to prevent a shutout. Christian Bethancourt, Sheldon Neuse and Nick Allen are riding four-game hitting streaks, with the latter having hit safely in six of seven contests and driving in five runs since being recalled from Triple-A Las Vegas.

How to make Athletics vs. Yankees picks

SportsLine's model is leaning under on the total, projecting 7.8 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Yankees vs. Athletics? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.