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The Cleveland Guardians visit Yankee Stadium for an afternoon tilt on Saturday. Cleveland is 7-6 overall and 4-3 on the road after a 4-1 loss to New York on Friday. The Yankees are 5-3 at home following the win, and this is the second game of a three-game weekend clash. New York enters at 8-6 overall. The Guardians have activated starting pitcher Cal Quantrill (1-0, 3.72 ERA) from the COVID-19 list and he'll take the hill in this one. Nestor Cortes (0-0, 0.00 ERA) is scheduled to get the start for New York. 

Caesars Sportsbook lists New York as the -185 (risk $185 to win $100) money-line favorite for this 1:05 p.m. ET first pitch. The total number of runs Vegas thinks will be scored, or the over-under, is 7.5 in the latest Yankees vs. Guardians odds. Before making any Guardians vs. Yankees picks, you need to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every MLB game 10,000 times, is off to a sizzling start to the 2022 season. It's on a 14-4 roll on top-rated MLB money-line picks through two weeks, returning over $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in on Yankees vs. Guardians, and just locked in its picks and MLB predictions. You can visit SportsLine now to see the model's picks. Here are the MLB odds and trends for Guardians vs. Yankees:

  • Yankees vs. Guardians money line: Yankees -185, Guardians +165
  • Yankees vs. Guardians over-under: 7.5 runs
  • Yankees vs. Guardians run line: Yankees -1.5 (+110)
  • CLE: The Guardians are 4-3 on the road
  • NYY: The Yankees are 5-3 at home

Why you should back the Guardians

Cleveland is led by a robust offense, and the Guardians deploy one of the best players in baseball. Standout infielder Jose Ramirez is arguably the leading early candidate for the AL MVP award, leading the league with 20 RBI in less than three weeks of action. Ramirez has four home runs and a .392/.439/.765 slash line, punishing opposing pitchers on a regular basis. As a team, Cleveland leads the AL in myriad categories, including runs scored with 69 in 13 games. The Guardians lead the league in batting average (.279), on-base percentage (.340), and slugging percentage (.441), with a top-three mark in doubles (26). 

Cleveland is also above-average in home runs (12) and strikeout avoidance, and the Guardians deploy an elite bullpen to help in run prevention. The Guardians have a 3.23 ERA with a reliever on the mound, with well over three strikeouts per walk. Cleveland relievers are generating 8.49 strikeouts per nine innings with only 2.55 walks per nine innings in 2022. 

Why you should back the Yankees

Cortes, the 27-year-old left-hander, has been lights-out. He had a 2.90 ERA in 93 innings last season, striking out more than a batter per inning and issuing only 2.42 walks per nine innings. 

In 2022, Cortes has been dominant, generating 17 strikeouts in 9.1 innings and allowing only six hits and one walk with no earned runs. When Cortes leaves the game, the Yankees can turn things over to an elite bullpen. New York leads the American League with a 2.08 ERA from its relievers, and the bullpen produces 10.11 strikeouts per nine innings with a stellar ground ball rate of 50.6 percent.

How to make Guardians vs. Yankees picks

SportsLine's model is leaning over on the total, projecting 8.6 combined runs, and it also says one side of the money line has all the value. You can only get the model's pick at SportsLine

So who wins Yankees vs. Guardians? And which side of the money line has all the value? Visit SportsLine now to see which side to jump on, all from the advanced model that has crushed its top-rated MLB picks, and find out.