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The Portland Trail Blazers visit Wells Fargo Center to meet the Philadelphia 76ers on Friday night. Portland is 31-35 overall, including 14-20 in road games, and the Blazers aim to avenge a loss to Philadelphia on Jan. 19. The 76ers are 43-22 overall, including four wins in the last five games and sport a 24-10 home record. Philadelphia has no injuries to report, while Anfernee Simons (ankle) listed as questionable for Portland.

Caesars Sportsbook lists the Sixers as 9-point home favorites, and tip-off is scheduled for 7 p.m. ET. The total number of points Vegas thinks will be scored, or the over/under, is 233 in the latest Blazers vs. 76ers odds. Before making any 76ers vs. Blazers picks, you'll want to see the NBA predictions and betting advice from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past four-plus seasons. The model enters Week 21 of the 2022-23 NBA season on a stunning 61-30 roll on all top-rated NBA picks this season, returning nearly $2,700. Anyone following it has seen huge returns.

Now, the model has set its sights on Sixers vs. Blazers and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and betting lines for Blazers vs. Sixers:

  • Blazers vs. 76ers spread: 76ers -9
  • Blazers vs. 76ers over/under: 233 points
  • Blazers vs. 76ers money line: 76ers -365, Blazers +285
  • POR: The Blazers are 16-18 against the spread in road games
  • PHI: The 76ers are 21-12-1 against the spread in home games
  • Blazers vs. 76ers picks: See picks at SportsLine
Featured Game | Philadelphia 76ers vs. Portland Trail Blazers

Why the Blazers can cover

Portland is keyed by Damian Lillard, who is enjoying an excellent season. The seven-time NBA All-Star and six-time All-NBA selection is averaging 32.3 points per game, ranking in the top three of the league, and Lillard adds 7.2 assists per game. In the last 19 games, Lillard is averaging 38.3 points per game while shooting 50.1% from the field and 40.5% from 3-point range, raising the ceiling of Portland's offense with individual brilliance. 

The Blazers are in the top eight of the NBA in offensive efficiency, scoring 115.8 points per 100 possessions, and that jumps to 119.7 points per 100 possessions over the last 20 games. Portland has strong shooting metrics, including 47.9% from the field, 37.3% from 3-point range, and 80.6% at the free throw line. The Blazers are also in the top quartile of the league in free throw creation (25.3 attempts per game), and Philadelphia is below-average in both free throw prevention (24.0 attempts allowed per game) and fast break points allowed (15.9 per game).

Why the 76ers can cover

Philadelphia's defense is clearly superior to Portland's, and the 76ers should also benefit from home-court advantage. The 76ers are in the top eight of the NBA in defensive efficiency, giving up fewer than 1.13 points per possession. Philadelphia is also in the top eight in assists allowed (23.7 per game) and 3-point percentage allowed (35.1%), with top-10 marks in points allowed in the paint (48.3 per game) and second-chance points allowed (12.8 per game).

On the other side, Portland is in the bottom five of the league in defensive efficiency, giving up 116.9 points per 100 possessions. The Blazers are also near the bottom of the NBA in field goal percentage allowed (48.7%) and assists allowed (26.2 per game), with the 76ers bringing an impressive pedigree at Wells Fargo Center. Philadelphia is 21-12-1 against the spread in home games this season, out-scoring opponents by 5.5 points per 100 possessions.

How to make 76ers vs. Blazers picks

SportsLine's model is leaning Under on the total, projecting 232 combined points. The model also says one side of the spread hits well over 50% of the time. You can only see the model's pick at SportsLine.

So who wins Blazers vs. 76ers? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its NBA picks.