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The Cincinnati Bengals have reached the AFC Championship Game the last two seasons and the Super Bowl played in February 2022. But their 2023 regular season has gotten off to a rough 1-3 start and they look to change their trajectory at the 1-3 Arizona Cardinals in Week 5. The Bengals enter off a 27-3 blowout loss at Tennessee, while the Cardinals fell 35-16 in San Francisco. Cincinnati is 0-3-1 against the spread this season, while Arizona is 3-1 ATS in 2023.

Kickoff is scheduled for 4:05 p.m. ET at State Farm Stadium. Cincinnati is favored by 3 points in the latest Bengals vs. Cardinals odds, and the over/under for total points scored is 45. Before making any Cardinals vs. Bengals picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2023 NFL season on an incredible 168-118 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 22-10 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bengals vs. Cardinals and just locked in its picks and NFL Week 5 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Cardinals vs. Bengals:

  • Cardinals vs. Bengals spread: Bengals -3
  • Cardinals vs. Bengals over/under: 45 points
  • Cardinals vs. Bengals money line: Bengals -168, Cardinals +141
  • Cardinals vs. Bengals picks: See picks at SportsLine
  • Cardinals vs. Bengals live stream: fubo (try for free)

Why the Bengals can cover

Through four games, Cincinnati's offense has been inept, likely due to the lingering calf injury suffered by quarterback Joe Burrow during training camp. The Bengals are averaging 12.3 points per game, second worst among any team, and they haven't scored a first half offensive touchdown. Burrow has thrown a combined 69 touchdown passes the last two seasons, but only has two in the 2023 season's first month.

If Burrow can improve his completion percentage from a career-low 57.6% to start 2023, Cincinnati's offense will improve rapidly. After all, the Bengals boast one of the league's top receivers, Ja'Marr Chase, who has caught 19 passes in the last two weeks. Running back Joe Mixon hasn't cleared 70 yards on the ground this season but looks to change that against an Arizona team that gave up 106 yards to Christian McCaffrey last week. See which team to pick here.

Why the Cardinals can cover

Arizona continues to play inspired football for new coach, Jonathan Gannon. Despite the 19 point score differential last weekend, the Cardinals fought until the end and gave San Francisco a worthy battle. QB Joshua Dobbs threw for 265 yards and two scores while rushing for 48 more yards on 12 attempts. Through four games, he's thrown for four touchdowns and no interceptions, an impressive feat considering that he wasn't acquired by Arizona until late in training camp.

RB James Conner has been reliable for the Cardinals, having rushed for 318 yards and two touchdowns on the season with a 5.1 yards per carry average. The team's top receiver, Marquise Brown, caught seven passes for 96 yards against San Francisco and now has 239 yards receiving and two scores in 2023. Rookie WR Michael Wilson trails Brown by only two yards following a 7-76-2 day against the 49ers. In what should be a close game, the Cardinals have a chance to upset the Bengals by playing a clean game and getting their playmakers involved early and often. See which team to pick here.

How to make Bengals vs. Cardinals picks

The model has simulated Cardinals vs. Bengals 10,000 times and the results are in. It is leaning Octer on the point total, and it also says one side of the spread hits well over 50% of the time. You can only see the model's Bengals vs. Cardinals pick at SportsLine.

So who wins Cardinals vs. Bengals on Sunday, and which side of the spread hits well over 50% of the time? Visit SportsLine right now to see which side of the Cardinals vs. Bengals spread you should be all over Sunday, all from the model on a 168-118 roll on its top-rated NFL picks, and find out.