NFL: NOV 01 Cowboys at Eagles
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The San Francisco 49ers will take on the Dallas Cowboys at 1 p.m. ET on Sunday at AT&T Stadium. Dallas is 4-9 overall and 2-4 at home, while the 49ers are 5-8 overall and 4-2 on the road. The 49ers have lost five of their past six games. The Cowboys have lost five of their past seven. 

San Francisco is favored by three points in the latest Cowboys vs. 49ers odds from William Hill Sportsbook, and the over-under is set at 45. Before entering any 49ers vs. Cowboys picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 22-11 on top-rated NFL picks this season, returning over $800. The model also enters Week 15 on an incredible 118-76 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Niners vs. Cowboys. You can head to SportsLine to see its picks. Here are several NFL betting lines for Cowboys vs. Niners:

  • Cowboys vs. 49ers spread: Cowboys +3
  • Cowboys vs. 49ers over-under: 45 points
  • Cowboys vs. 49ers money line: Dallas +140, 49ers -160

What you need to know about the Cowboys

The Cowboys made easy work of the Cincinnati Bengals this past Sunday in a 30-7 victory. Dallas scored 17 first half points, including a 78-yard fumble return for a TD by Aldon Smith. In his return to Cincinnati, Andy Dalton passed for 185 yards and two TDs vs. zero INTs for a 122.6 rating. He has two-plus TD passes in three of his past four starts. 

Amari Cooper had four catches for 51 yards and a TD last week. He is the only player with five-plus TD catches in each of the past six seasons. Cooper is aiming for his fourth game in a row with a TD. He needs 58 yards for his fifth career season with 1,000 yards. Tyrone Crawford had his second career two-sack game last week. Dallas has won five of the past six meetings with San Francisco. This will be the first time since 2014 that the Cowboys will host the 49ers. 

What you need to know about the 49ers

Meanwhile, the Niners lost to the Washington Football Team this past Sunday, 23-15. Two of Nick Mullens' turnovers were returned for scores. The 49ers have turned over the ball multiple times in seven straight games, the team's longest such streak since an eight-game run of misfortune in 2018. It was San Francisco's second consecutive loss at its temporary home venue in Arizona. 

Rookie Brandon Aiyuk led the team with career-high 10 receptions and a career-high 119 yards last week. He is shooting for his sixth game in a row with five-plus receptions and 75-plus yards. Deebo Samuel could potentially miss the rest of the season with a hamstring injury. Jeff Wilson Jr. had his fifth rushing TD of the season last week. He has five TDs (four rushing) in his past three road games. The Cowboys are worst in the NFL in rushing yards allowed per game, with 162.7 on average. 

How to make 49ers vs. Cowboys picks

The model has simulated Cowboys vs. 49ers 10,000 times and the results are in. It is leaning over on the total, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Cowboys vs. 49ers? And which side of the spread hits has all the value? Visit SportsLine now to see which side of the Cowboys vs. 49ers spread to jump on Sunday, all from the model that enters Week 15 of the NFL season on an incredible 118-76 roll.