The attention of the NFL world will be on Lucas Oil Stadium for Monday Night Football. The Indianapolis Colts will welcome the Pittsburgh Steelers to town for the finale of Week 12. Indianapolis is 1-1 under interim head coach Jeff Saturday, posting a 4-6-1 overall record this season. Pittsburgh is 3-7 overall after a seven-point home loss to the Cincinnati Bengals in its last game. 

Kickoff is at 8:15 p.m. ET in Indianapolis. Caesars Sportsbook lists the Colts as 2.5-point home favorites, while the over/under, or total number of points Vegas thinks will be scored, is 39.5 in the latest Steelers vs. Colts odds. Before you make any Colts vs. Steelers picks and NFL predictions, you need to see what SportsLine NFL expert R.J. White has to say.

White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine's No. 1 NFL expert in picks against the spread and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He's also gone a whopping 56-32-4 on his last 92 picks involving the Steelers, meaning he's well-qualified for this selection. 

He's well-known for cashing out big in the Westgate Las Vegas SuperContest twice since 2015. White also cashed big on his NFL futures in 2021, including nailing Jonathan Taylor as the NFL rushing leader at 10-1. Anyone who has followed White is way up.

Now, White has set his sights on Steelers vs. Colts and just locked in his picks and NFL predictions. You can head to SportsLine now to see his picks. Now, here are several NFL odds and betting lines for Steelers vs. Colts:

  • Steelers vs. Colts spread: Colts -2.5
  • Steelers vs. Colts over/under: 39.5 points 
  • Steelers vs. Colts money line: Colts -140, Steelers +118 
  • PIT: Steelers are 4-5-1 against the spread this season 
  • IND: Colts are 5-6 against the spread this season 
  • Steelers vs. Colts picks: See picks here
Featured Game | Indianapolis Colts vs. Pittsburgh Steelers

Why the Steelers can cover

Indianapolis is averaging only 15.7 points per game this season, second-fewest in the NFL, and the Colts are averaging only 1.40 points per drive. The Colts are scoring on fewer than 30% of offensive drives, and Indianapolis has 19 turnovers, third-most in the league. Indianapolis is in the bottom 10 in total offense, averaging 321.7 yards per game, and the Colts are below the league average in passing yards and rushing yards.

Indianapolis is averaging only 4.1 yards per rush attempt and 5.5 net yards per pass attempt. The Colts are also No. 25 in third down efficiency (36.9%) and No. 30 in red zone efficiency (43.3%). With Pittsburgh's elite run defense and the ability to create havoc with 14 forced turnovers this season, it is a friendly matchup for the Steelers. See which team to pick here.

Why the Colts can cover

Pittsburgh's usually potent defense has clear shortcomings in 2022. The Steelers are No. 26 in points allowed (24.4 per game), and Pittsburgh is No. 27 in total yards allowed (375.5 per game). Pittsburgh is especially vulnerable through the air, with the league's worst mark in pass defense (272.1 yards allowed per game) and passing touchdowns allowed (22). Indianapolis has improved in the passing game with Matt Ryan back at the helm, and the former NFL MVP is No. 3 in completion rate at 69.2%. Ryan has completed at least 70% of his passes in six of his last seven starts for Indianapolis and ranks in the top 10 in passing yards (2,443) and completions (247).

On the ground, Jonathan Taylor is a strong option for the Colts, and the 2021 All-Pro led the league in rushing yards (1,811) and rushing touchdowns (18) last season. Taylor is in the top five with 86.6 rushing yards per game and has 231 yards and two touchdowns in the last two games. See which team to pick here.

How to make Steelers vs. Colts picks

White has analyzed this matchup and while we can tell you he's leaning Under on the point total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Colts vs. Steelers on Monday Night Football? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Colts vs. Steelers spread to back, all from the expert who is 56-32 on picks involving the Steelers, and find out.