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NFL Week 6 wraps up with a Monday Night Football matchup between the Los Angeles Chargers and the Dallas Cowboys at SoFi Stadium in Inglewood, Calif.. Kickoff is at 8:15 p.m. ET. Quarterbacks Dak Prescott and Justin Herbert headline a star-studded NFL DFS player pool. Both teams also have Pro Bowl wide receivers -- Keenan Allen for the Chargers and CeeDee Lamb for the Cowboys -- who can be paired with their respective quarterbacks when making NFL DFS stacks. Should you include the Chargers' duo or the Cowboys' duo in your NFL DFS picks and NFL DFS lineups? Before making any NFL DFS picks for Chargers vs. Cowboys on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who cashed big all season in 2022, has covered the NFL and college football for over a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.  

Kaylor hit on epic NFL DFS picks all season in 2022. He was all over Travis Kelce's four-touchdown performance against the Raiders on Monday Night Football, Kirk Cousins' 460-yard, four-TD performance on Thanksgiving Day, and T.J. Hockenson's 13 catches for 109 yards and two touchdowns in Week 15.

In the Week 2 Eagles vs. Vikings Thursday Night Football matchup Kaylor was all over Justin Jefferson (11-159), D'Andre Swift (175-1), DeVonta Smith (4-132-1), and T.J. Hockenson (7-66-2). Anyone who followed his picks cashed in big.

Now, Kaylor has turned his attention to the Week 6 Chargers vs. Cowboys matchup on Monday Night Football and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Chargers vs. Cowboys on MNF

One of Kaylor's favorite NFL DFS picks for MNF is Los Angeles running back Austin Ekeler. The 28-year-old running back has been sidelined since Week 1, but he enters this matchup completely healthy with no injury designation. Ekeler has proven to be one of the top all-purpose backs in the NFL, and is one of Justin Herbert's favorite targets. In a matchup that could turn into an offensive shootout, Kaylor expects Ekeler to see plenty of action.

"The Chargers' offense is completely different when Austin Ekeler is healthy. The former Division-II All-American is perhaps the best pass catching running back in the NFL and serves as a security blanket of sorts for quarterback Justin Herbert. With the Cowboys' elite pass rush coming to town on Monday night, I expect Ekeler to be targeted frequently out of the backfield on underneath routes and screen passes. When you factor in all of his expected impact, I am projecting 20+ touches for Ekeler on MNF," Kaylor told SportsLine.

Part of Kaylor's MNF DFS strategy also includes rostering Cowboys wide receiver CeeDee Lamb. The former first-round pick out of Oklahoma is one of the most explosive wide receivers in the NFL, and faces a Chargers' secondary that has struggled at times in 2023. Los Angeles ranks dead last in the NFL in passing defense, allowing 299.8 yards per game, and Kaylor expects Lamb to shine on Monday Night Football. 

"The Chargers' secondary has been susceptible and struggled against high-powered passing attacks all season. After last week's dud of a performance, I expect the Cowboys to come out firing and target CeeDee Lamb early and often. Lamb is a threat to score every time he touches the ball, and I'd be shocked if the Cowboys don't make a noticeable effort to increase his touches against the Chargers on Monday night," Kaylor said. You can see the rest of Kaylor's NFL DFS picks here.

How to build NFL DFS lineups for Cowboys vs. Chargers on MNF

Kaylor is also targeting another undervalued player who could explode for huge numbers for Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor's MNF DFS picks, at SportsLine

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Monday Night Football, and which under-the-radar NFL DFS picks offer sky-high value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament, and find out.