The New England Patriots will try to get back on track when they battle the Arizona Cardinals in a key matchup on Monday Night Football. The Patriots (6-6), who are looking to reach the NFL playoff bracket for the second consecutive season, have made the playoffs 18 times in the past 21 years, winning six Super Bowl championships during that span. The Cardinals (4-8), meanwhile, will see their postseason hopes all but dashed with another loss. Arizona is trying to make the playoffs for the second consecutive year and just the seventh time since the franchise moved to Phoenix in 1988. Patriots wide receiver Jakobi Meyers (concussion) and Cardinals receiver Rondale Moore (groin) are both inactive.

Kickoff from State Farm Stadium in Glendale, Ariz., is set for 8:15 p.m. ET. New England is a 2.5-point favorite in the latest Patriots vs. Cardinals odds from Caesars Sportsbook, while the over/under for total points scored is 44. Before locking in any Cardinals vs. Patriots picks or NFL bets, you should check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 14 of the 2022 NFL season on an incredible 156-112 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has broken down Patriots vs. Cardinals on MNF. You can head to SportsLine to see the picks. Here are the NFL lines and trends for Cardinals vs. Patriots:

  • Patriots vs. Cardinals spread: New England -2.5
  • Patriots vs. Cardinals over/under: 44 points
  • Patriots vs. Cardinals money line: Patriots -135, Cardinals +115
  • NE: Patriots are 12-2 against the spread in their last 14 games following a double-digit home loss
  • ARI: Cardinals are 5-2 ATS in their last seven games following a straight-up loss
  • Patriots vs. Cardinals picks: See picks at SportsLine
Featured Game | Arizona Cardinals vs. New England Patriots

Why the Patriots can cover

New England's defense has been stout all season. Linebacker Matthew Judon had his first fumble recovery of the season last week. For the year, he is among the team leaders in tackles with 46, including 26 solo. He had a sack in his only career game against Arizona as a member of the Baltimore Ravens on Sept. 15, 2019, and has had plenty of success on Monday Night Football, registering 3.5 sacks in his past two games. Judon ranks second in the NFL with 13 sacks this season.

Linebacker Josh Uche had career-high seven tackles, two sacks and his first-career forced fumble in Week 13. He looks for his third game in a row with a sack. For the season, Uche has 19 tackles, including 17 solo, with seven sacks for 27 yards and five tackles for loss. He had six tackles, including five solo, with three sacks in a win over Indianapolis on Nov. 6. See which team to pick here.

Why the Cardinals can cover

Wide receiver Deandre Hopkins had 87 receiving yards and his third receiving touchdown of the season in the Week 12 loss to the Los Angeles Chargers. He has 85-plus receiving yards in five of his six games in 2022. He needs one catch for his ninth-career 50-catch season. Since 2013, he leads the NFL in receptions (838) and ranks second in receiving yards (11,155). He will be looking for his fifth game in a row versus New England with five or more catches and has 50 or more receiving yards in 11 of his 12 career Monday Night Football games.

Wide receiver Marquise Brown will be out for his seventh game in a row with five or more catches. He has five receiving touchdowns in five career MNF games and will be looking for his fourth game in a row on Monday Night Football with a touchdown catch. For the season, Brown has 49 receptions for 531 yards (10.8 average) and three touchdowns. He has eight explosive plays of 20 yards or more, including a long of 26 yards, and has converted 26 first downs. See which team to pick here.

How to make Cardinals vs. Patriots picks

The model has broken down Monday Night Football's Patriots vs. Cardinals matchup from all angles. It is leaning Under the total, with the model projecting 42 combined points. It also says one side of the spread cashes in more than 50% of simulations. See who it is at SportsLine.

So who wins Cardinals vs. Patriots on Monday Night Football? And which side of the spread cashes over 50% of the time? Visit SportsLine now to find out which side of the Cardinals vs. Patriots spread you should be all over, all from the model on a 156-112 roll on its top-rated NFL picks, and find out.