The Seattle Seahawks and the San Francisco 49ers will face off in an NFC West clash at 4:05 p.m. ET on Sunday at Levi's Stadium. San Francisco is 2-1 overall, while the Seahawks are 1-2. The Seahawks lost to the Vikings last week, 30-17. The Niners fell to the Packers, 30-28.
The Seahawks have won three of the past four meetings between the teams. San Francisco is favored by 2.5 points in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, and the over-under is set at 52. Before entering any Seahawks vs. 49ers picks, you'll want to see the NFL predictions from the model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 4 of the 2021 season on an incredible 123-81 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Seahawks vs. Niners. You can head to SportsLine to see its picks. Here are several NFL betting lines for Niners vs. Seahawks:
- 49ers vs. Seahawks spread: 49ers -2.5
- 49ers vs. Seahawks over-under: 52 points
What you need to know about the 49ers
Jimmy Garoppolo has thrown two-plus TD passes and no interceptions in his last two home games vs. NFC West teams. Deebo Samuel had five receptions for 52 yards last week. He is second in the NFL with 334 receiving yards. Samuel has five-plus catches in seven of his last eight games.
Brandon Aiyuk had his first TD catch of the season last week. He finished with eight catches for 91 yards and a TD in his only career game vs. the Seahawks. George Kittle (calf) and Elijah Mitchell (shoulder) are listed as questionable for Week 4.
What you need to know about the Seahawks
Russell Wilson leads the league with a 133.6 QB, rating. He has two-plus TD passes in six of his past seven games against the 49ers. DK Metcalf had six catches for 107 yards and a TD in Week 3. He has 27 receptions for 333 yards and three TDs in four career matchups with the 49ers.
Tyler Lockett had 12 receptions for two TDs and 90 yards in his last meeting with San Francisco. Chris Carson has averaged 108 rushing yards per game in five career games vs. the 49ers. Jamal Adams tied a career high with 12 tackles last week.
How to make 49ers vs. Seahawks picks
The model has simulated 49ers vs. Seahawks 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.
So who wins 49ers vs. Seahawks? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.
