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Teams looking to get back into the postseason clash when the Indianapolis Colts meet the San Francisco 49ers in a Sunday Night Football showdown. The Colts (2-4), who are second in the AFC South, are looking to earn their second consecutive playoff berth and 17th in the past 23 seasons. The 49ers (2-3), who are third in the NFC West, are looking for their second postseason appearance in three years. After going 13-3 and earning a trip to the Super Bowl in 2019, San Francisco dipped to 6-10 a year ago due to numerous injuries. The 49ers are looking to bounce back.

The game from Levi's Stadium in Santa Clara, Calif., is slated to start at 8:20 p.m. ET. The Colts have done a good job taking care of the football and are tied for third in the NFL with a plus-seven turnover differential, while the 49ers are tied for 29th at minus-five. San Francisco is favored by 3.5 points in the latest Colts vs. 49ers odds from Caesars Sportsbook, while the over-under for total points scored is 41.5. You'll want to see what SportsLine's Tom Fornelli has to say before laying any Colts vs. 49ers picks down.

The CBS national writer went a profitable 31-22 last season on his NFL best bets. What's more, he has demonstrated a particularly sharp eye for the 49ers. In fact, Fornelli has gone a stunning 15-6 on picks involving San Francisco, returning more than $850 to $100 players. Anyone who has followed him is way up.

Now, Fornelli has zoned in on Colts vs. 49ers and released his NFL picks and predictions. You can head to SportsLine now to see his picks. Here are the NFL lines and trends for Colts vs. 49ers:

  • 49ers vs. Colts spread: San Francisco -3.5
  • 49ers vs. Colts over-under: 41.5
  • 49ers vs. Colts money line: Indianapolis +150, San Francisco -175
  • IND: The Colts are 4-2 against the spread this season
  • SF: The over is 4-0 in the 49ers' last four games following an ATS loss
Featured Game | San Francisco 49ers vs. Indianapolis Colts

Why the 49ers can cover

San Francisco's defense has a number of playmakers, led by defensive lineman Nick Bosa, who missed all but two games last season due to injury. He is back and is once again a force as Bosa had a sack and two tackles for loss in Week 5. He is looking for his third game in a row with a sack and sixth in a row with a tackle for loss. He has 24 tackles for loss in 23 career games. In five games this season, Bosa has 19 tackles, including 14 solo, with five sacks, eight tackles for loss and one forced fumble.

Also powering the defense is linebacker Fred Warner, who had a team-high nine tackles in Week 5. He has nine or more tackles in six of his past seven games and is looking for his fourth game in a row with nine or more tackles. Warner leads the team with 45 tackles, 29 of which are solo, including two tackles for loss. He also has one pass breakup.

Why the Colts can cover 

After struggling early in the season, Indianapolis has been playing much better of late. Wide receiver Michael Pittman Jr. is a big part of the offense, and leads all Colts receivers with 31 receptions for 403 yards (13 average) and one touchdown. He has five explosive plays and 19 first-down conversions. Pittman has 50 or more receiving yards in four of the past five games. His best game was an eight-catch, 123-yard performance against the Rams in Week 2.

Wide receiver Zach Pascal has also made his presence felt, making 18 receptions for 204 yards (11.3 average) and three touchdowns. He has three explosive plays of 20 or more yards and has converted nine first downs. In the 28-16 season-opening loss to the Seattle Seahawks, Pascal had four receptions for 43 yards and two touchdowns. In four seasons with the Colts, Pascal has appeared in 54 games with 130 receptions for 1,708 yards (13.1 average) and 15 touchdowns.

How to make Colts vs. 49ers picks

For Sunday Night Football, Fornelli is leaning over on the point total, but he also says a critical X-factor makes one side of the spread a must-back. Fornelli is only sharing his 49ers vs. Colts picks at SportsLine. 

So who wins Colts vs. 49ers on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Colts vs. 49ers spread you need to jump on, all from the expert who returned more than $850 to $100 players in the last 21 San Francisco games, and find out.