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A pair of Top 25 teams clash on Wednesday when the No. 18 North Carolina Tar Heels face the No. 10 Indiana Hoosiers in an ACC-Big Ten Challenge matchup in Bloomington, Ind. The Tar Heels (5-2), who are 2-4 all-time at Indiana, have a two-game losing streak, which has plummeted them 17 spots in the polls after being No. 1 last week. The Hoosiers (6-0), who are 8-13 all-time in the ACC/Big Ten Challenge, are 5-4 in the games played at home. Indiana is 3-1 in the Challenge against North Carolina.

The game from Assembly Hall is set for 9:20 p.m. ET. North Carolina is averaging 82.6 points per game, while Indiana averages 88.8. The Hoosiers are 4.5-point favorites in the latest North Carolina vs. Indiana odds from Caesars Sportsbook, while the over/under for total points scored is set at 145.5. Before making any Indiana vs. North Carolina picks, be sure to check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,500 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on North Carolina vs. Indiana and just locked in its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Indiana vs. North Carolina:

  • North Carolina vs. Indiana spread: Indiana -4.5
  • North Carolina vs. Indiana over/under: 145.5 points 
  • North Carolina vs. Indiana money line: Indiana -190, North Carolina +160
  • UNC: The Tar Heels are 3-0-2 against the spread in their last five games following a straight-up loss 
  • IND: The Hoosiers are 9-2-1 ATS in their last 12 games overall 
  • North Carolina vs. Indiana picks: See picks here
Featured Game | Indiana Hoosiers vs. North Carolina Tar Heels

Why Indiana can cover

Senior forward Trayce Jackson-Davis, a consensus Preseason All-American, averages 18.8 points, eight rebounds and two assists per game. He is on a number of watch lists, including the John R. Wooden Award Preseason Top 50 Watch List and the NABC Division I Player of the Year Watch List. He scored a team-best 30 points to go along with six rebounds, two assists and three blocks in the road win over Xavier on Nov. 18. He is coming off an 11-point, five-rebound effort in the win over Jackson State on Friday.

Senior guard Xavier Johnson has 14 career 20-point games and is averaging 11 points, 4.8 assists and 3.8 rebounds per contest. In his career at Indiana and Pittsburgh, Johnson has scored 1,631 points. He is coming off a 16-point, four-assist and two-steal effort against Jackson State, and fell short of a double-double with nine points and 10 assists in the win over Little Rock on Nov. 23. He scored 23 points and grabbed seven rebounds at Xavier.

Why North Carolina can cover 

Junior guard Caleb Love has had a number of monster performances already this year, including a season-high 34 points and nine rebounds in Sunday's loss to Alabama. He has reached double figures in six of seven games, including a 25-point, nine-rebound effort against Charleston on Nov. 11. For the season, he is averaging 20 points, 4.9 rebounds, 3.4 assists and 1.7 assists per game. Love has averaged double-figure scoring all three years he's been at North Carolina.

The Tar Heels' other top scoring option is senior forward Armando Bacot. Bacot is averaging a double-double with 16.7 points and 11.3 rebounds per game. He also has 11 blocks on the year and eight assists. He has three double-doubles, including a 19-point, 23-rebound effort against James Madison on Nov. 20. He also had 20 points and 10 rebounds against Alabama on Sunday.

How to make North Carolina vs. Indiana picks

SportsLine's model is leaning Under on the point total. It has also generated an against-the-spread pick that cashes in over 60% of simulations. You can only get the model's pick at SportsLine

So who wins Indiana vs. UNC? And which side of the spread hits in over 60% of simulations? Visit SportsLine now to see which side of the North Carolina vs. Indiana spread to jump on, all from the advanced model that is up more than $1,500 on its college basketball picks the last six years, and find out.