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Red Sox starter Nick Pivetta looks to go 6-0 when he and the Boston Red Sox take on the Atlanta Braves on Wednesday at Fenway Park in Boston. The 28-year-old Pivetta is having his best start to a season in his career. In four previous seasons, mostly in the National League, he went 26-25. This year, Boston is 8-1 in his nine starts. On Wednesday, the Red Sox are the -121 money-line favorite in the latest Red Sox vs. Braves odds from William Hill Sportsbook, while the Braves are +110 underdogs. First pitch is set for 7:10 p.m. ET.

That is one of the marquee matchups among the 15 games on Wednesday's MLB schedule. Other top games include the White Sox hosting the Cardinals in a matchup of two division leaders and the Dodgers looking to win their ninth straight game on Wednesday against the Astros. Before you lock in your MLB picks on those games or any others Wednesday night, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 61-44 on top-rated MLB money-line picks through eight weeks, returning well over $700. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Wednesday and posted its best bets for the evening games. Parlaying these four MLB picks would pay more than 11-1. Head to SportsLine to see the picks

Top MLB picks for Wednesday, May 26

The model likes the Nationals (-135) to beat the Reds at 7:05 p.m. ET. Washington (20-24) enters the game in last place in the tight NL East but just three games behind the division-leading Mets. Meanwhile, Cincinnati (21-25) sits in fourth in the NL Central.

Nationals starter Joe Ross has had success recently against the Reds. The 28-year-old righty is 2-0 with a 1.32 ERA in his last two starts against Cincinnati. Meanwhile, Reds starter Jeff Hoffman has struggled on the road this season, going 0-2 with a 6.06 ERA. In addition, Washington has won five of its last six homes games against Cincinnati. 

How to make MLB predictions, parlays for Wednesday, May 26

The model has locked in three other MLB best bets, including one on a big underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Wednesday for a shot at a big return of more than 11-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Wednesday's top MLB picks, all from the projection model off to a fast start in 2021, and find out.