The rival Los Angeles Dodgers and San Francisco Giants play the second game of the four-game series on Friday night at Dodger Stadium in Los Angeles. The Dodgers (31-19) sit in second place in the loaded NL West, a half-game behind the division-leading Padres. The Giants (30-20) are 1.5 games behind. Los Angeles won the series opener on Thursday, 4-3. On Friday, the Dodgers are -203 money-line favorites in the latest Dodgers vs. Giants odds from William Hill Sportsbook, while the Giants are +183 underdogs.

That is one of the marquee matchups among the 14 games on Friday's MLB schedule. Other top games include the Padres (32-19), who have the best record in baseball, taking on the Astros in Houston and two former No. 1 overall picks -- the Yankees' Gerrit Cole and the Tigers' Casey Mize -- facing off at Comerica Park in Detroit. Before you lock in your MLB picks on those games or any others Friday night, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 61-44 on top-rated MLB money-line picks through eight weeks, returning well over $700. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Friday and posted its best bets for the evening games. Parlaying these four MLB picks would pay almost 28-1. Head to SportsLine to see the picks

Top MLB picks for Friday, May 28

The model likes the Cardinals (+120) to beat the Diamondbacks at 9:40 p.m. ET. The Cardinals (28-22) won the opening game of the four-game series on Thursday night, 5-4 in 10 innings. The loss was the Diamondbacks' 11th consecutive defeat.

Arizona's pitching staff is one of the worst in the majors. The Diamondbacks have a 4.93 ERA and a 1.40 WHIP this season; both rank 27th in baseball. The bullpen has been particularly poor, with a 1.53 WHIP (28th in the majors) and a 5.09 ERA (26th). In addition, the Diamondbacks have won just one of their last eight games at home. 

Featured Game | Arizona Diamondbacks vs. St. Louis Cardinals

How to make MLB predictions, parlays for Friday, May 28

The model has locked in three other MLB best bets, including one on a big underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Friday for a shot at a big return of almost 28-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Friday's top MLB picks, all from the projection model off to a fast start in 2021, and find out.