The San Francisco Giants can stretch their winning streak to six when they host the Bay Area rival Oakland Athletics in the second game of a two-game series on Wednesday at Oracle Park. The Giants (13-5) own the second best record in the majors and share the longest active winning streak with the Twins. On Wednesday, Sam Long takes the mound for San Francisco against Paul Blackburn. San Francisco is a -180 money line favorite in the latest Giants vs. A's odds from Caesars Sportsbook, while Oakland is a +155 underdog. First pitch is set for 9:45 p.m. ET.
Elsewhere in the majors, the Mets look to sweep the Cardinals, and Shohei Ohtani takes the mound for the Angels against the Guardians. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 25-11 roll on top-rated MLB money-line picks through three weeks, returning almost $1,100 for $100 players. Anyone following it has seen huge returns.
Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games at 6:40 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of almost 12-1. You can see the model's MLB picks for Wednesday only at SportsLine.
Top MLB picks today
After simulating every game 10,000 times, the model is high on the Blue Jays (-140) beating the Red Sox. The Blue Jays (12-6) already have won the first two games of the four-game series between the teams, winning 6-2 on Monday and 6-5 in 10 innings on Tuesday. The Red Sox (7-11) have now dropped four straight games and six of their last seven.
Michael Wacha (1-0, 1.88 ERA) is set to start for Boston, and the Blue Jays blasted him the last time they faced him. On Sept. 15 of last season, Wacha allowed six runs on seven hits and two walks in six innings in a 6-3 Toronto win. Bo Bichette went 2-for-2 with a home run and four RBI against Wacha in that game.
How to make MLB picks and parlays for Wednesday
The model also locked in three other best bets for Wednesday, including a play on a big American League underdog. You can see the model's MLB Wednesday best bets and parlay only at SportsLine.
What MLB picks should you target for a payout of almost 12-1? And what underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 25-11 roll on top-rated MLB money-line picks through three weeks, and find out.
