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Astros ace Justin Verlander will try to continue his strong start to the season when he and the Houston Astros open a three-game series on Friday against the Seattle Mariners at T-Mobile Park in Seattle. The 39-year-old Verlander (6-1, 1.22 ERA) leads the majors in ERA and WHIP (0.72) and is tied for the lead in wins. On Friday, he squares off against Chris Flexen (1-6, 4.98). Houston is a -200 money-line favorite in the latest Astros vs. Mariners odds from Caesars Sportsbook, while Seattle is a +175 underdog. First pitch is set for 9:40 p.m. ET. 

The game is one of 14 on the MLB schedule for Friday. Elsewhere in the majors, the Brewers and Cardinals continue their NL Central showdown in St. Louis, and the Yankees and Rays play the second game of their key four-game series in the Bronx. Before making any MLB picks or parlays, be sure to check out the baseball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in three confident MLB best bets for Friday. The games don't start until 7:10 p.m. ET, so there's still plenty of time to get your MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of 11-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

After simulating every game on Friday 10,000 times, the model is high on the Blue Jays (-120) beating the Angels in that 9:38 p.m. ET first pitch (see tickets at StubHub). On Thursday, the Blue Jays took the first game of the four-game series with a 6-3 victory. In that mathcup, Toronto got home runs from George Springer and Vladimir Guerrero Jr. and beat Angels two-way Shohei Ohtani in the process.

The game continued a hot streak for Springer. The All-Star centerfielder has hit safely in nine straight games and is hitting .313 with two homers and five RBI over that stretch. For the season, Springer leads Toronto in homers (nine), RBIs (26), slugging percentage (.530) and OPS (.882).

Featured Game | Los Angeles Angels vs. Toronto Blue Jays

How to make Friday MLB parlays

The model also locked in three other best bets for Friday, including a play on a big National League underdog. You can see the model's MLB Friday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of 11-1? And what big underdog does the model like on Friday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 41-30 roll on top-rated MLB money-line picks through seven weeks.