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Since losing four straight from April 19-23, the Houston Astros have been one of the hottest teams in the major leagues, winning 17 of their last 21 contests. Nine of those victories have come on the road, where they have gone 14-8 this season and won five of six on their current nine-game trip. The trek continues Monday as the Astros open a three-game series against the Boston Red Sox, who have lost five in a row at home and are just 4-9 there this year. Boston is a -125 money-line favorite in the latest Red Sox vs. Astros odds from Caesars Sportsbook, while Houston is a +105 underdog.

First pitch at Fenway Park is set for 7:10 p.m. ET. The game is one of 11 on the MLB schedule for Monday evening. Other matchups include the Los Angeles Angels visiting the Texas Rangers and the Toronto Blue Jays hosting the Seattle Mariners in the openers of their three-game series. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and is off to a sizzling start to the 2022 season. It's on a 33-25 roll on top-rated MLB money-line picks through six weeks, returning over $300 for $100 players. Anyone following it has seen some huge returns.

Now, the model has locked in four confident MLB best bets for Monday. All the games occur at 7:07 p.m. ET or later, so there's still plenty of time to make these MLB picks. If you successfully parlay the picks, you'd be looking at a payout of almost 12-1. You can only see the model's MLB picks at SportsLine.

Top MLB picks today

The model, which simulated every game on Monday's schedule 10,000 times, is taking the Mariners (+1.5 at -140) to cover against the Blue Jays in their series opener at 7:07 p.m. ET (see tickets at StubHub). Seattle is coming off a weekend during which it won two of three one-run games at New York to hand the Mets their first loss in 11 series this season.

The Mariners, who have seen five of their last seven contests be decided by a single run, erupted for a season high-tying 16 hits in Sunday's 8-7 victory. Rookie Julio Rodriguez went 4-for-4 with a homer and two RBI, Ty France posted the fourth two-hit performance of his five-game hitting streak and Jesse Winker extended his run to seven contests with a 2-for-5 effort. Seattle right-hander Chris Flexen is just 1-5 with a 4.24 ERA but pitched well in his last road start, allowing one run and two hits over five innings in a loss at Houston. Meanwhile, Toronto has struggled mightily of late, losing nine of its last 12 games and scoring three runs or fewer in five of its past seven.

Featured Game | Toronto Blue Jays vs. Seattle Mariners

How to make MLB picks and parlays for Monday

The model also locked in three other best bets for Monday, including a pair of must-see plays on underdogs. You can see the model's MLB Monday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of almost 12-1? And what underdogs does the model like on Monday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 33-25 roll on top-rated MLB money-line picks through six weeks.