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The Minnesota Vikings will take on the San Francisco 49ers at 4:25 p.m. ET on Sunday at Levi's Stadium. San Francisco is 5-5 overall and 1-4 at home, while the Vikings are 5-5 overall and 2-3 on the road. The Niners have won three of their last four games. Minnesota has won two consecutive games. 

The Vikings have won four of the past five games between the teams. San Francisco is favored by three points in the latest 49ers vs. Vikings odds from Caesars Sportsbook, and the over-under is set at 49. Before entering any Vikings vs. 49ers picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Vikings. You can head to SportsLine to see its picks. Here are several NFL betting lines for Vikings vs. Niners:

  • 49ers vs. Vikings spread: 49ers -3
  • 49ers vs. Vikings over-under: 49 points
Featured Game | San Francisco 49ers vs. Minnesota Vikings

What you need to know about the 49ers

The 49ers routed the Jacksonville Jaguars last Sunday, 30-10 on the road. Deebo Samuel had 94 scrimmage yards (career-high 79 rushing) and his third rushing TD of the season. He became the first WR in the Super Bowl era with three-plus rushing TDs in two of his first three seasons. George Kittle caught a TD pass in his third consecutive game. 

Nick Bosa had two sacks in Week 11 and has a career-high 10 sacks in 2021. Josh Norman leads the league with six forced fumbles. Elijah Mitchell (rib/finger) is listed as questionable for Sunday's game. 

What you need to know about the Vikings

Meanwhile, Minnesota edged the Green Bay Packers, 34-31. Greg Joseph made a 29-yard field goal as time expired. Kirk Cousins passed for 341 yards and three touchdowns. He has 25 games with 300-plus passing yards and three-plus TD passes, the second-most by an NFL QB in his first 10 seasons all-time.

Justin Jefferson had eight receptions for 169 yards and two TDs. He has 11 games with 100-plus receiving yards, tied for the second-most by a WR in his first two seasons in the Super Bowl era. Adam Thielen had eight catches for 82 yards and his eighth receiving TD of the season last week. 

How to make Vikings vs. 49ers picks

The model is leaning over on the total, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins 49ers vs. Vikings? And which side of the spread has all the value? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.