The New England Patriots will take on the Arizona Cardinals at 1 p.m. ET on Sunday at Gillette Stadium. New England is 4-6 overall and 3-2 at home, while Arizona is 6-4 overall and 3-2 on the road. The Patriots had won back-to-back games before last week's loss. The Cardinals have lost two of their past three games.
Arizona is favored by 1.5 points in the latest Patriots vs. Cardinals odds from William Hill Sportsbook, and the over-under is set at 49. Before entering any Cardinals vs. Patriots picks, you'll want to see the NFL predictions from the model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up more than $7,800 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 19-10 on top-rated NFL picks this season, returning almost $800. The model also enters Week 12 on an incredible 115-75 run on top-rated NFL picks that dates back to the 2017 season.
The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.
- Patriots vs. Cardinals spread: Patriots +1.5
- Patriots vs. Cardinals over-under: 49 points
- Patriots vs. Cardinals money line: New England +110, Arizona -130
What you need to know about the Patriots
New England fell to Houston 27-20 this past Sunday. With six games remaining, the Patriots have already lost as many games as they did in any season since 2002, matching their 2005 and 2009 totals. Cam Newton passed for 365 yards and one TD. New England is coming into this week with the fewest passing touchdowns in the league, having accrued only six on the season. Rex Burkhead suffered a season-ending knee injury in the loss to the Texans.
Damiere Byrd had six catches for a career-high 132 yards and a TD last week. He had 32 catches for 359 yards and TD in 2019 with Arizona. James White had a season-high 83 scrimmage yards (64 receiving) and six catches last week. J.C. Jackson has an interception in five of his past six games. Bill Belichick has a 4-1 record vs. Arizona. The Patriots have won six of the last seven meetings with the Cardinals.
What you need to know about the Cardinals
Meanwhile, Arizona came up short against Seattle, 28-21, in its last game. Kyler Murray was sacked three times and took seven quarterback hits. He suffered a shoulder injury, but played through it and he is expected to start vs. New England. Murray has eight games with both a passing and rushing TD in 2020, tied for the most in a single season in NFL history. He has two-plus TD passes in four of his past five games.
Arizona enters the game with 16 rushing touchdowns, which is the best in the NFL. Kenyan Drake has eight rushing TDs in his past seven road games. Chase Edmonds has a TD in four of his past five road games. DeAndre Hopkins had just five catches for 51 yards last week, but at age 28, he became the youngest player to reach 700 career receptions in NFL history. He is the fifth player with 700-plus catches in his first eight seasons. Isaiah Simmons had a career-high 10 tackles and his first career sack vs. Seattle.
How to make Patriots vs. Cardinals picks
The model has simulated Patriots vs. Cardinals 10,000 times and the results are in. It is leaning under on the total, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.
So who wins Cardinals vs. Patriots? And which side of the spread has all the value? Visit SportsLine now to see which side of the Cardinals vs. Patriots spread to jump on Sunday, all from the model that enters Week 12 of the NFL season on an incredible 115-75 roll.