The New Orleans Saints will take on the Jacksonville Jaguars in the finale of a busy week of NFL preseason games. New Orleans is aiming for its first preseason win, as they took it easy in a 17-14 loss to the Baltimore Ravens last week with multiple starters resting. Jacksonville also lost its opener, falling 23-13 to the Cleveland Browns. Quarterback is at the forefront for both squads, with No. 1 pick Trevor Lawrence battling Gardner Minshew for playing time in Jacksonville and former No. 1 pick Jameis Winston facing Taysom Hill in a quarterback contest for New Orleans.

Kickoff is at 8 p.m. ET in New Orleans. Caesars Sportsbook lists the Saints as four-point favorites at home, while the over-under, or total number of points Vegas thinks will be scored, is 39.5 in the latest Jaguars vs. Saints odds. Before you make any Saints vs. Jaguars picks, make sure to check out the expert NFL predictions from SportsLine NFL expert Mike Tierney

A national sportswriter whose work appears in The New York Times and Los Angeles Times, Tierney has covered the NFL for decades and reported from seven Super Bowls. Tierney does not consider himself a pet lover. But he likes 'dogs, preferring to evaluate each game from the underdog's point of view. Tierney has used that philosophy to crush the NFL, going 187-147 against the spread the past three seasons.

In addition, Tierney has gone an astounding 23-12 on his last 35 picks involving Jacksonville, returning more than $1,000. Anyone who has followed him is way up.

Now, Tierney has set his sights on Jaguars vs. Saints and just revealed his NFL expert picks and predictions. You can head to SportsLine now to see his picks. Now, here are several NFL odds and betting trends for Saints vs. Jaguars:

Jaguars vs. Saints odds, spread, over-under, money line

  • Jaguars vs. Saints spread: Saints -4
  • Jaguars vs. Saints over-under: 39.5 points
  • Jaguars vs. Saints money line: Saints -210, Jaguars +180
  • JAC: The Jaguars were 7-9 against the spread last season
  • NO: The Saints were 10-8 against the spread in 2020
Featured Game | New Orleans Saints vs. Jacksonville Jaguars

Why the Jaguars can cover

Jacksonville likely has a greater sense of urgency in this game. For one, Urban Meyer is trying to establish a new culture for the Jaguars. They have three primary running backs, led by 1,000-yard rusher James Robinson, while top draft pick Travis Etienne brings a versatile element. That depth also gives the Jaguars an advantage in that they can fill more snaps with starting-caliber talent. That also applies at wide receiver, with familiar faces like Tavon Austin and Laquon Treadwell competing for roster spots and playing time, while Marvin Jones Jr. looked good in the opener with three catches for 52 yards in limited time.

Jacksonville has three quarterbacks that can do the job in a preseason setting, with C.J. Beathard throwing for 102 yards and a touchdown in the opener as the third-string option. Indications are that the Jaguars will take a longer look at both Trevor Lawrence (6-9 for 71 yards in the opener) and Gardner Minshew (4-8 for 47 yards and an interception). Jacksonville hasn't won a preseason game since 2019, and they have incentive to push against a veteran Saints team that is simply easing into the season.

Why the Saints can cover

New Orleans rested key pieces up and down the roster in the opener, making the final result a bit misleading. Some of those standouts are projected to return to action this week, headlined by Marshon Lattimore, Cam Jordan and Alvin Kamara. New Orleans projects to be a standout defensive team, and the Jags will be operating without two starting offensive linemen, Brandon Linder and Andrew Norwell.

Standout wide receiver D.J. Chark could also miss the game with a finger issue following surgery and the Jags were No. 30 in the NFL in scoring offense last season. On the opposite side, the Saints have an ongoing competition between Jameis Winston and Taysom Hill that could lead to increased usage of quality quarterbacks. In fact, third-stringer Ian Book was excellent in the opener, and increased faith at that position could swing the pendulum to New Orleans. 

How to make Saints vs. Jaguars picks

Tierney is leaning over on the point total, and he's also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing that pick at SportsLine

So who wins Jaguars vs. Saints? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Mike Tierney's Saints vs. Jaguars pick and analysis, all from the NFL expert who's 23-12 on picks involving Jacksonville, and find out.