There have been plenty of difficult decisions to make for NFL office pool picks during the first two weeks of the season, but the Week 3 NFL schedule might be even trickier. Caesars Sportsbook has eight games lined within three points in the latest Week 3 NFL odds, including a monster showdown between Green Bay and Tampa Bay. Aaron Rodgers and the Packers are 1.5-point underdogs to Tom Brady and the Buccaneers, so that game will likely be placed near the bottom of the list in most people's NFL confidence pool picks. The bigger favorites on the board include the Chargers (-7) against the Jaguars and the Eagles (-6.5) at Washington. Should those favorites be ranked high in your Week 3 NFL pool picks? Before you make your NFL predictions, you need to see the Week 3 NFL football pool picks from SportsLine's proven model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 3 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Go to SportsLine to see them now.

Top Week 3 NFL office pool predictions

One of the top Week 3 NFL predictions from the model: The Minnesota Vikings (-6) earn a strong win at home against the Detroit Lions. Minnesota has faced a pair of projected playoff teams so far this season, splitting games against Green Bay and Philadelphia.

Minnesota has one of the strongest offenses in the NFL, led by quarterback Kirk Cousins, running back Dalvin Cook and wide receiver Justin Jefferson. The Vikings also boast backup running back Alexander Mattison and veteran wideout Adam Thielen, so it could be difficult for Detroit's offense to keep pace. SportsLine's model expects Cousins to throw for more than 300 yards and the rushing attack to record more than 110 yards, which leads to Minnesota winning this game in over 70% of simulations. See the rest of the model's Week 3 NFL pool picks here.

How to make Week 3 NFL office pool picks

The model also made the call on every other Week 3 NFL game and has strong picks for potentially close matchups like 49ers vs. Broncos and Titans vs. Raiders. It's also calling for several big favorites to struggle more than expected and several shocking teams to hang tough. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 3 NFL game? And which underdog pulls off a huge upset? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the top 10 on straight-up picks four of the last six years and went an outstanding 139-102 on top-ranked picks against the spread since 2017.