Week 5 of the 2022 NFL regular season is chock-full of storylines. Daniel Jones and Co. are in London, as the Giants will look to register an upset victory over Aaron Rodgers and the Packers, Patriots rookie quarterback Bailey Zappe gets a chance to wow home fans in his first career start against a porous Lions defense and Cooper Rush and the Cowboys have an opportunity to build on their hot start with a win over the reigning Super Bowl champion Rams in L.A.
As we do every week, we've collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them all in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Ready? Let's jump in!
All NFL odds via Caesars Sportsbook.
Which picks can you make with confidence in Week 5? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up almost $7,000 for $100 players on top-rated NFL picks since its inception.
San Francisco 49ers at Carolina Panthers
Time: Sunday, 4:05 p.m. ET (CBS), stream on Paramount+ (click here)
Open: 49ers -3.5
"The Carolina Panthers are the most unwatchable team in the NFL. If Watchability Rankings aren't a thing yet, they should be, and the Panthers would be 32nd for four straight weeks. The 49ers should stomp Carolina -- the only concern is how the San Francisco offensive line handles a good Panthers pass rush. Can Jimmy Garoppolo score 21 points? I say yes, which means the Niners win this one and probably cover with the way that defense is playing right now."
CBS Sports senior analyst and Pick Six Podcast host Will Brinson is fading Carolina this week. To read his breakdown of each game this weekend and his best bets, click here.
Philadelphia Eagles at Arizona Cardinals
Time: Sunday, 4:25 p.m. ET (Fox), stream on fuboTV (try for free)
Open: Cardinals -3
"The Eagles are one of the top teams in the NFL this season, and they have covered in each of their past three games after failing to do so in their season opener against the Detroit Lions. I've made them a best bet to cover in each of the past two weeks, so why stop now? The Eagles look like a complete team to me. Jalen Hurts and the offense have been the headline -- and I can understand why. The Eagles lead the NFL in "big plays" this season with 36. If you were wondering, "big plays" are rushes of at least 10 yards and passes of at least 20 yards.
The Eagles have run 184 offensive plays with the lead this season, which is the most in the NFL, while the Cardinals have run 13 offensive plays with the lead this season, which is the worst in the NFL. The Cardinals defense has been interesting to watch, as they blitz at the highest rate in the NFL (41%), but are allowing a 125.8 passer rating with blitz, which ranks No. 29 in the NFL. Hmm.
Arizona doesn't really have home-field advantage, as the Cardinals have lost seven straight home games -- which is the longest such streak in the NFL. But here's the key stat: The Cards have failed to cover in all seven of those home games as well."
CBS Sports' Jordan Dajani is on Philly once again this week. To read his Week 5 picks column, click here.
Dallas Cowboys at Los Angeles Rams
Time: Sunday, 4:25 p.m. ET (Fox), stream on fuboTV (try for free)
Open: Rams -5.5
"As much as I'd like to ramble on here about how the Cowboys are only good because of Cooper Rush, I'm not going to do that because it's not exactly true. The Cowboys are 3-1 right now because their defense is destroying everyone: They can stop the run, they can stop the pass and they are exceptionally good at embarrassing opposing quarterbacks.
The Cowboys have totaled 15 sacks this season, which is the second-highest total in the NFL. On the other hand, the Rams offensive line has been banged up all year, which has turned the first four weeks of the season into a nightmare for Matthew Stafford.
If you saw what happened to Stafford in Week 1 -- he got sacked seven times against the Bills --- then you got a taste of what might happen to him this week. If you saw what happened to Matthew Stafford on Monday night -- he got sacked seven times against the 49ers --- then you got a taste of what might happen to him this week. Stafford has been sacked 16 times this season, which is tied for the second-most in the NFL, and based on what I've seen from the Cowboys defense, they might double that total.
The problem for the Rams is that they almost never win win Stafford gets sacked two or more times in a game. In Stafford's 22 regular season games with the team, the Rams are 11-1 when he gets sacked one time or less, but just 3-6 when he gets sacked multiple times. Basically, the Rams have a tough time winning when Stafford is getting beat up.
The other thing about the Cowboys defense is that no one can score on them. The Cowboys have yet to surrender 20 points in any game this year, which is impressive when you consider that they've already faced quarterbacks like Joe Burrow and Tom Brady.
Since Dak Prescott went down, the Cowboys' formula for winning games has been pretty simple: Play great defense and pray that Cooper Rush doesn't make any mistakes on offense. Well, the prayers have clearly been working because Rush has zero interceptions through four weeks. I have no idea if the Cowboys will be sticking with Rush for one more week or turning the offensive reigns over to Dak Prescott, but I don't care, I'm taking them no matter what."
CBS Sports NFL expert John Breech is riding with "America's Team" this week. To read his best bets for Week 5, click here.
Cincinnati Bengals at Baltimore Ravens
Time: Sunday, 8:20 p.m. ET (NBC), stream on fuboTV (try for free)
Open: Ravens -2.5
Before you make any Bengals vs. Ravens picks or any other NFL predictions, you need to see which side Mike Tierney is on. A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney has covered the NFL for decades and reported from seven Super Bowls. Over the past four seasons, Mike is 232-204 ATS in the NFL. In addition, Tierney has gone 33-14-1 on his last 48 picks involving the Ravens, returning $1,750. Anyone who has followed him is way up.
We can tell you he's leaning Under the total, but to see his against-the-spread pick for this matchup, head over to SportsLine.
Las Vegas Raiders at Kansas City Chiefs
Time: Monday, 8:15 p.m. ET (ESPN), stream on fuboTV (try for free)
Open: Chiefs -6
SportsLine expert Larry Hartstein is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 against the spread coming into the 2022 season. On top of that, Hartstein has gone 24-10 on his last 34 picks involving the Chiefs, returning $1,280 so you'll definitely want to see where he is leaning on Monday night. To see his pick for Chiefs-Raiders, head on over to SportsLine.