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The Arizona Cardinals look to win their second game of the season and snap their three-game losing streak to the Seattle Seahawks as they face off in Week 7. Arizona (1-5) fell on the road to the Rams, 26-9, while Seattle lost a close one at Cincinnati, 17-13. The Seahawks won both matchups last season by exactly 10 points. Arizona is 3-3 against the spread, while Seattle is 3-2 ATS this season.

Kickoff at Lumen Field in Seattle is scheduled for 4:05 p.m. ET. Seattle is favored by 9 points in the latest Seahawks vs. Cardinals odds, and the over/under for total points scored is 44.5. Before making any Cardinals vs. Seahawks picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2023 NFL season on an incredible 172-120 run on top-rated NFL picks that dates back to the 2017 season. It also is on a 26-12 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cardinals vs. Seahawks and just locked in its picks and NFL Week 7 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Seahawks vs. Cardinals:

  • Seahawks vs. Cardinals spread: Seahawks -9
  • Seahawks vs. Cardinals over/under: 44.5 points
  • Seahawks vs. Cardinals money line: Seahawks -446, Cardinals +343
  • Seahawks vs. Cardinals picks: See picks at SportsLine
  • Seahawks vs. Cardinals live stream: fubo (try for free)

Why the Cardinals can cover

The Cardinals might be better positioned to succeed later this season when quarterback Kyler Murray and running back James Conner return from injury. While Joshua Dobbs has been solid, Murray is a game-breaking talent with his arm and his legs. In the meantime, Arizona has to rely on Dobbs and a backfield of Keaontay Ingram, Damien Williams, and Emari Demercado to shoulder the load this weekend. Last week, the three running backs combined to rush 20 times for 87 yards against the Rams.

Wide receiver Marquise Brown is the Cardinals' best player currently available on offense and has posted a respectable 29 catch, 334 yard, three touchdown season thus far. With Seattle's defense being fifth-worst against the pass in 2023 (257.6 yards per game), Dobbs and Brown may find success against this unit. Tight end Zach Ertz also looks to extend his consecutive games with a catch streak to 123 on Sunday. See which team to pick here.

Why the Seahawks can cover

Will the Cardinals have enough defensive firepower to slow all of Seattle's offensive weapons? Running back Kenneth Walker III has 345 yards and three rushing scores on 83 carries thus far this season in addition to 100 yards receiving on 11 receptions. With Arizona's rushing defense surrendering 133.3 yards per game (ninth worst in the league), it's conceivable to expect a plentiful day from Seattle's top rusher.

Quarterback Geno Smith hasn't been as effective as he was in 2022, though he has plenty of receivers to work with in D.K. Metcalf, Tyler Lockett. and first round draft pick Jaxon Smith-Njigba. Smith has only thrown for 1,172 yards with five touchdowns and three interceptions thus far and likely will need to improve as the season goes along for Seattle to be more successful. Metcalf (22-337-2) leads the team in receiving yards, while Lockett (23-251-2) leads in receptions. Slot receiver Smith-Njigba, who was extremely productive at Ohio State, seems due for a breakout game to boost his 16-110-0 season statistics. See which team to pick here.

How to make Cardinals vs. Seahawks picks

The model has simulated Seattle vs. Arizona 10,000 times and the results are in. It is leaning Over on the point total, and it also says one side of the spread hits well over 50% of the time. You can only see the model's Cardinals vs. Seahawks pick at SportsLine.

So who wins Seahawks vs. Cardinals on Sunday, and which side of the spread hits well over 50% of the time? Visit SportsLine right now to see which side of the Cardinals vs. Seahawks spread you should be all over Sunday, all from the model on a 172-120 roll on its top-rated NFL picks, and find out.